天然产物研究与开发2017，Vol.29Issue(7)：1107-1112,6.DOI:10.16333/j.1001-6880.2017.7.005
乌贼墨汁黑色素对链脲佐菌素诱导的糖尿病模型小鼠糖脂代谢的调节作用
Regulation Effects of Sepia Ink Melanin on Glucose-Lipid Metabolism in Streptozotocin-induced Diabetic Mice
摘要
Abstract
In this study,the effects of sepia ink melanin (SIM) on glucose-lipid matabolism in diabetics mice induced by streptozotocin were investigated.Mice were randomly divided into 4 groups [normal group,model group,melanin (120,480 mg/kg) groups] with 10 mice in each group.Animals were gavaged with SIM or equal volume saline.After 4weeks,a series of index were measured including glycated hemoglobin (HbA1c),glycosylated serum protein (GSP),fasting blood glucose,food intake,water intake,oral glucose tolerance test,serum insulin and insulin resistance index.The results showed that SIM significantly alleviated the level of glucose-lipid metabolism,and promoted the secretion of insulin in diabetic mice.In conclusion,sepia melanin ink (SIM) can ameliorate the symptom of diabetic mice through controlling blood sugar concentration,promoting the secretion of insulin and regulating glucose-lipid metabolism disorder.关键词
黑色素/糖尿病/胰岛素抵抗指数/糖化血红蛋白/糖化血清蛋白Key words
melanin/diabetes/insulin resistance index/HbA1c/GSP分类
生物科学引用本文复制引用
董慧,王春琳,宋微微,母昌考,李荣华..乌贼墨汁黑色素对链脲佐菌素诱导的糖尿病模型小鼠糖脂代谢的调节作用[J].天然产物研究与开发,2017,29(7):1107-1112,6.基金项目
浙江省自然科学基金(LQ12C19002) （LQ12C19002）
浙江省公益性项目(ZX2013000403) （ZX2013000403）
宁波大学“水产”重中之重学科开放基金 （）
宁波市重大农业专项(201401C1111001) （201401C1111001）
大学生创新孵化项目(2016R405096) （2016R405096）
