天然产物研究与开发2017，Vol.29Issue(7)：1171-1176,6.DOI:10.16333/j.1001-6880.2017.7.016
壳聚糖-海藻酸钠靛玉红自微乳缓释微囊制备、评价及体外释放的研究
Preparation, Evaluation and in vitro Release on Chitosan Alginate Sustained Release Microcapsule of Indirubin Self Microemulsion
摘要
Abstract
In this study,indirubin self-microemulsion was used as core material,chitosan and sodium alginate were used as wall materials to prepare chitosan-alginate indirubin self-emulsifying microcapsules by complex coacervation method.The preparation process was optimized by single factor and orthogonal experiments.Then the quality evaluation was carried out with the drug loading and encapsulation efficiency.At the same time,the drug release property was evaluated with the drug release in vitro.The optimal preparation process was determined as follows:The concentration of sodium alginate was 1.5％,the proportion of indirubin self-microemulsion volume,sodium alginate volume and chitosan mass was 1 ∶ 1 ∶ 0.5,the optimal concentration of calcium chloride was 2％.The drug loading rate and encapsulation rate of microcapsules prepared by the optimized process was 0.0416％ and 79.2％,respectively.The cumulative release rate of 24 h in vitro was (97.1 ± 2.68) ％.The release of the microcapsules conformed to the Higuchi equation and one-order kinetics,hence it had a better sustained release effect.关键词
靛玉红自微乳/缓释微囊/海藻酸钠/壳聚糖Key words
indirubin self-microemulsion/microcapsules/sodium alginate/chitosan分类
医药卫生引用本文复制引用
蒋瑶,王云红,裴太蓉,冉继春,刘楠..壳聚糖-海藻酸钠靛玉红自微乳缓释微囊制备、评价及体外释放的研究[J].天然产物研究与开发,2017,29(7):1171-1176,6.基金项目
重庆市科委基本科研业务项目(2016cstc-jbky-01902) （2016cstc-jbky-01902）
