无机材料学报2017，Vol.32Issue(8)：837-844,8.DOI:10.15541/jim20160628
三维打印羟基磷灰石晶须增强复合骨修复支架
Hydroxyapatite Whisker-reinforced Composite Scaffolds Through 3D Printing for Bone Repair
摘要
Abstract
Development of bioactive scaffolds with controllable architecture and high osteogenic capability is essen-tial for bone tissue engineering. In this study, hydroxyapatite whiskers (HAPw) were added into polycaprolactone (PCL) matrix materials to fabricate scaffolds through 3D printing technique. The HAPw could distribute homogene-ously in PCL and in alignment with 3D printing directions by adjusting squeeze parameters. The mechanical strength of PCL-HAPw composite scaffolds increased along with the increase of HAPw content. Adding 33wt％ of HAPw remarkably enhanced the compressive strength of PCL scaffolds to 3 times, which can also lower the surface contact angles from 100° of PCL to 50° and thus enhance the surface hydrophilicity.In vitro culturing experiments of human bone marrow mesenchymal cells (hBMSCs) demonstrated that the incorporation of HAPw promoted their bioactive and osteogenic properties, including better cytocompatibility, cell adhesion, proliferation, alkaline phosphatase (ALP) activity, and bone-related gene expressions (OCN, RUNX2). Therefore, 3D-printed HAPw-PCL composite scaffolds showed improved mechanical strength and osteogenesis properties compared to pure PCL scaffolds, and suggest promising applications in bone regeneration.关键词
三维打印/羟基磷灰石晶须/支架/骨修复Key words
3D printing/hydroxyapatite whiskers/scaffolds/bone regeneration分类
化学化工引用本文复制引用
辛晨,齐鑫,朱敏,赵世昌,朱钰方..三维打印羟基磷灰石晶须增强复合骨修复支架[J].无机材料学报,2017,32(8):837-844,8.基金项目
国家自然科学基金青年项目(51302170) （51302170）
上海市教委科研创新项目(14YZ085) National Natural Science Foundation of China (51302170) （14YZ085）
Innovation Program of Shanghai Municipal Education Commission (14YZ085) （14YZ085）
