医药导报2017，Vol.36Issue(9)：1024-1028,5.DOI:10.3870/j.issn.1004-0781.2017.09.019
灯盏花素微乳注射剂的制备
Preparation of Breviscapine Microemulsion for Parenteral Injection
摘要
Abstract
Objective To study the prescription and preparation technology of breviscapine microemulsion for parenteral injection,and to evaluate its quality.Methods The prescription was selected and optimized through single-factor test and the pseudo-ternary phase diagram method.The preparation technology was investigated,and the particle diameter,drug content,encapsulation efficiency and haemolyticus were evaluated.Results The prescription composition of breviscapine microemulsion was soybean oil:phospholipid:HS15:PEG400:water=1:0.1:0.55:0.55:6.64 (m/m),with the drug content of 4.01 mg·mL-1,the acquired breviscapine microemulsion exhibited light yellow,uniform and transparent,with average particle diameter of 92.1 nm and encapsulation efficiency of 96.8%.The compatibility test showed no drug precipitation and the preparation was no hemolytic crisis.Conclusion The preparation of breviscapine microemulsion injection is correspond to the main index of parenteral injection.关键词
灯盏花素/微乳/伪三元相图Key words
Breviscapine/Microemulsion/Pseudo-ternary phase diagram分类
医药卫生引用本文复制引用
赵晴,李海刚,刘浩,林桂,闵庆强,杨晓彤..灯盏花素微乳注射剂的制备[J].医药导报,2017,36(9):1024-1028,5.基金项目
2015年地方高校国家级大学生创新创业训练计划项目(201510452027) （201510452027）
