医药导报2017，Vol.36Issue(9)：1033-1037,5.DOI:10.3870/j.issn.1004-0781.2017.09.021
超高效液相色谱-质谱联用法测定不同粒径活血散透皮吸收液中4种成分含量
Determination of Four Kinds of Ingredients in Transparent Absorbent Fluid of Different Size of Huoxue Powder by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry
摘要
Abstract
Objective To optimize the particle size of Huoxue powder by contents comparison of emodin,phellodendrine,berberine and jatrorrhizine before and after permeabilized skin absorption of Huoxue powder in different particle size of 0.150,0.075,0.048,0.038 mm.Methods The contents of emodin,phellodendrine,berberine and jatrorrhizine in transparent absorbent fluid of Huoxue power in different particle size within 24 hours were measured by ultra performance liquid chromatography tandem mass spectrometry,and optimize its particle size by contents comparison of the effective components.Results The contents of the active components in Huoxue power with the particle size of 0.075 mm were high before and after percutaneous absorption.Conclusion Particle size of 0.075 mm is best for Huoxue powder.关键词
活血散/大黄素/黄柏碱/小檗碱/药根碱/超高效液相-色谱质谱联用/透皮吸收Key words
Huoxue powder/Phellodendrine/Berberine/Jatrorrhizine/Ultra performance liquid chromatography tandem mass spectrometry/Percutaneous absorption/Emodin分类
医药卫生引用本文复制引用
杨炳火,周芙琼,朱维娜,李文,赵颖..超高效液相色谱-质谱联用法测定不同粒径活血散透皮吸收液中4种成分含量[J].医药导报,2017,36(9):1033-1037,5.基金项目
南京市医学科技发展项目(YKK14141) （YKK14141）
