中国美容医学2017，Vol.26Issue(8)：80-82,3.
芳香烃受体信号通路在皮肤肿瘤中的表达
The Expression of Aryl Hydrocarbon Receptor (AHR) Signal Pathway in Skin Tumors
摘要
Abstract
Objective To study the expression of AHR and CYP1A1 in normal skin, actinic keratosis(AK), bowen disease and skin squamous cell carcinoma. Methods Immunohistochemical method was used to detect the expression of AHR and CYP1A1 protein in 15 cases of normal skin, 10 cases of AK, 10 cases of Bowen disease and 20 cases of skin SCC. Results The expression of AHR in normal skin, AK, Bowen disease and skin SCC was 33%, 100%, 80% and 65%, respectively. The positive rates of AHR in the cell nucleus were 20%, 70%, 60% and 50% respectively. The positive rates of CYP1A1 in normal skin, AK, Bowen disease and skin SCC were 20%, 20%, 20% and 15%, respectively. Conclusion The high expression and activation of AHR is related to the occurrence of skin SCC and is worthy of further studies of its role in the pathogeneses of skin tumors.关键词
芳香烃受体/AK/鲍温病/鳞状细胞癌Key words
aryl hydrocarbon receptor/actinic keratosis/bowen disease/squmous cell carcinoma分类
医药卫生引用本文复制引用
潘展砚,陈佳,胡婷婷,吴伊旋,王辰樑,鞠强..芳香烃受体信号通路在皮肤肿瘤中的表达[J].中国美容医学,2017,26(8):80-82,3.基金项目
国家自然科学基金(81602772) （81602772）
上海市自然科学基金(14ZR1424900) （14ZR1424900）
