中国兽医科学2017，Vol.38Issue(8)：945-950,6.DOI:10.16656/j.issn.1673-4696.2017.08.002
重组免疫融合肽Tα1-BP5对鸭坦布苏病毒灭活疫苗的免疫增强作用
Enhancing immune effects of the recombinant fusion peptide (Tα1-BP5) on DTMUVA inactivated vaccine
摘要
Abstract
In order to explore the immunological functions of the recombinant fusion peptide Tα1-BP5 and investigate adjuvant effects associated with DTMUVA.In this study,ducklings were immunized with rTα1-BP5 combined with DTMUVA inactivated vaccine to detect the levels of IgG antibody,IL-4,IFN-γ,lymphocyte proliferation and virus neutralization.Virus challenge experiment was used to evaluate the immune protection of ducklings.The results showed that rTα1-BP5 could enhance IgG antibody level,increase the level of cytokine secretion,and increase the proliferation of lymphocyte in vivo and the titer of virus neutralization.The results revealed that rTα1-BP5 could enhance the immune responses in ducklings and protect the duck liver from damages.This study laid the foundation for research of immunological adjuvants for DTMUVA inactived vaccines.关键词
rTα1-BP5/鸭坦布苏病毒/灭活疫苗/免疫佐剂Key words
rTα1-BP5/DTMUVA/inactivated vaccines/immunologic adjuvant分类
农业科技引用本文复制引用
张聪,张巫凡,周江飞,廖成水,李小康,王臣..重组免疫融合肽Tα1-BP5对鸭坦布苏病毒灭活疫苗的免疫增强作用[J].中国兽医科学,2017,38(8):945-950,6.基金项目
国家自然科学青年基金项目(31101792,31201928) （31101792,31201928）
河南省高校青年骨干教师项目(2012GGJS-077) （2012GGJS-077）
