中国现代医学杂志2017，Vol.27Issue(18)：32-37,6.DOI:10.3969/j.issn.1005-8982.2017.18.006
＜3岁反复喘息患儿外周血血清ORMDL3基因在不同临床表型中的表达及其与IL-17和ECP的关系
Surum expression of ORMDL3 gene and its relationships with IL-17 and ECT in recurrent wheezing patients under 3 years
郑虹 1王威 1何昭 1刘金宝 1钟剑1
作者信息
- 1. 广东省惠州市第一人民医院儿科,广东惠州516000
- 折叠
摘要
Abstract
Objective To investigate the expression of orosomucoid l-like protein 3 (ORMDL3) gene of different clinical phenotypes and its relationship between seruminterleukin-17 (IL-17),serum eosinophil cationic protein (ECP) in peripheral blood of the recurrent asthma patients no more than 3 years old.Methods Eighty recurrent asthma children no more than 3 years old admitted to our hospital were selected and divided into atopic asthma group (64 cases) and non-atopic asthma group (23 cases) according to the existence of high risk factors.In the same period 30 cases of healthy children were selected in the control group.The differences of ORMDL3 gene expression,serum IL-17,serum ECP,and ORMDL3 gene frequency distribution in the three groups were analyzed,and the correlations of ORMDL3 gene expression level with serum IL-17 content,serum ECP content in the 3 groups were analyzed.Results The expression levels of ORMDL3 gene (1354.46 ± 873.48)pg/ml and serum ECP content (45.65 ± 12.76)μg/L in the atopic asthma group were higher than those in the non-atopic asthma group and the control group (P =0.000).The distribution of AA,AG and GG genotypes of ORMDL3 had no significant difference among the 3 groups (x2=12.84,P =0.012).The expression levels of ORMDL3 gene was positively related with serum IL-7 (r=0.318,P=0.000) and serum Eop (r =0.540,P =0.000) in the atopic group.Conclusions The serum expression levels of ORMDL3 gene,ECP and IL-17 are different among asthma children with different clinical phenotypes.The expression level of ORMDL3 gene in the serum of atopic asthma patients no more than 3 years old is related to the levels of serum IL-17 and ECP.关键词
反复喘息/特应性哮喘/非特应性哮喘/黏蛋白1样蛋白3基因Key words
recurrent asthma/atopic asthma/non-atopic asthma/orosomucoid 1-like protein 3 gene分类
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郑虹,王威,何昭,刘金宝,钟剑..＜3岁反复喘息患儿外周血血清ORMDL3基因在不同临床表型中的表达及其与IL-17和ECP的关系[J].中国现代医学杂志,2017,27(18):32-37,6.
