摘要
Abstract
Objective To compare the efficacy of Enalapril combined with Nifedipine controlled release tablets in the treatment of elderly patients with coronary heart disease complicated with hypertension.Method Selected 80 patients treated in Xijing Hospital from March 2014 to March 2016 as objects of study, all patients were randomly divided into study group (40 cases) and control group (40 cases). Control group patients were treated with Nifedipine controlled release tablets only, study group patients were treated with Enalapril combined with Nifedipine controlled release tablets. Serum creatinine, serum potassium and serum uric acid levels were compared before and after treatment between the two groups. The changes of systolic pressure (SBP), diastolic pressure (DBP), pulse pressure and ischemic status during treatment, adverse drug reactions and clinical curative effects were analyzed.Result After treatment, the levels of serum creatinine and serum potassium in study group were significantly higher than those before treatment and control group (P<0.05), the levels of serum uric acid was significantly lower than before treatment and control group (P<0.05). The total effective rate in study group was significantly higher than that in control group (χ2=5.5411,P=0.0186). The SBP, DBP, pulse pressure in study group were significantly lower than control group (P<0.05). After treatment, SBP, DBP, pulse pressure reduced significantly in both groups (P<0.05). The ischemic status in study group was significantly lower than that in control group (χ2=7.3837,P=0.0066). There was no significantly difference in adverse drug reactions between the two groups (P>0.05).Conclusion The combination of Nifedipine controlled release tablets and Enalapril in the treament of elderly patients with coronary heart disease complicated with hypertension, can not only improve the symptoms of hypertension, reduce the blood pressure level, but also improve the clinical curative effect, and the safety is high, it is worthy of clinical reference.关键词
冠心病/高血压/老年/依那普利/硝苯地平控释片Key words
Coronary heart disease/Hypertension/Elderly/Enalapril/Nifedipine controlled release tablets
