中国肿瘤生物治疗杂志2017，Vol.24Issue(8)：884-888,5.DOI:10.3872/j.issn.1007-385x.2017.08.012
lncRNA NCRNA00173在骨肉瘤组织中的表达及其临床意义
Expression and clinical significance of lncRNA NCRNA00173 in osteosarcoma tissues
摘要
Abstract
Objective:To investigate the expression and clinical significance of lncRNA NCRNA00173 in the tissues of osteosarcoma patients.Methods:The expression of lncRNA NCRNA00173 mRNA was detected in 54 cases of osteosarcoma tissues and adjacent tissues (collected from the patients underwent surgery between October,2012 and December,2016 at the Department of Orthopedic,Sichuan Provincial People's Hospital) by real-time fluorescence quantification PCR,and its clinical significance was analyzed.Results:The expression of lncRNA NCRNA00173 in osteosarcoma tissues was obviously decreased compared with that in paracarcinoma tissues (1.793±0.158 vs 5.368±0.285,t=10.96,P＜0.01).LncRNA NCRNA00173 expression was not significantly correlated with patients' gender or age (both P＞0.05),but remarkably correlated with disease stage,distant metastasis,tumor differentiation and the survival (all P＜0.05);Furthermore,patients with high lncRNA NCRNA00173 expression had significant longer OS and median PFS.Cox multivariate regression analysis suggested that IncRNA NCRNA00173 expression,distant metastasis and clinical stage were the independent prognostic factors for osteosarcoma (P＜0.05).Conclusion:IncRNA NCRNA00173 is involved in the occurrence and development of osteosarcoma,and can be used as a molecular marker for the diagnosis and prognosis of osteosarcoma.关键词
lncRNA NCRNA00173/骨肉瘤/临床意义Key words
lncRNA NCRNA00173/osteosarcoma/clinical significance分类
医药卫生引用本文复制引用
潘海霞,杨兰,胡洪林,白义凤..lncRNA NCRNA00173在骨肉瘤组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2017,24(8):884-888,5.基金项目
四川省科技支撑项目资助(No.2012SZ0181).Project support by the Science and Technology Program of Sichuan (No.2012SZ0181) （No.2012SZ0181）
