中国肿瘤生物治疗杂志2017，Vol.24Issue(8)：889-894,6.DOI:10.3872/j.issn.1007-385x.2017.08.013
lncRNA CRNDE在非小细胞肺癌组织中的表达及其临床意义
Expression and clinical significance of lncRNA CRNDE in patients with nonsmall cell lung cancer
摘要
Abstract
Objective:To investigate the expression and clinical significance of lncRNA CRNDE (colorectal neoplasia differentially expressed) in NSCLC(non-small cell lung cancer) tissues.Methods:137 cases of NSCLC tissues and corresponding para-cancerous tissues from patients with NSCLC who underwent radical or palliative resection in General Hospital of Chengdu Military Region from January 1,2011 to December 31,2015 were collected for this study;Meanwhile,29 cases of normal lung tissues from patients suffered from traumatic injury were used as controls.The expression of lncRNA CRNDE in 137 cases of NSCLC tissues and adjacent tissues were detected by QRT-PCR method,and the relationship between its expression and clinical pathological characteristics and prognosis of NSCLC were analyzed.Results:Compared with the para-cancerous tissues (1.098±0.082),the average expression level of lncRNA CRNDE in cancer tissues (5.283±0.245) was significantly higher with statistical significance (t=14.59,P＜0.001).lncRNA CRNDE expression was significantly correlated with disease stage,distant metastasis,pathological type and survival status (all P＜0.05),but not associated with age,gender,smoking,tumor size,lymph node metastasis and tumor difference (all P＞0.05).The high lncRNA CRNDE expression was related to the pathological type of NSCLC (P＜ 0.05),and the expression of lncRNA CRNDE in adenocarcinoma group was significantly higher than that in squamous cell carcinoma and other groups.Moreover,Kaplan-Meier analysis demonstrated that the progression-free survival time in patients with high lncRNA CRNDE expression (20± 1.72 months) was shortened compared with the patients with low expression (34.07± 1.97 months),the difference was statistically significant (x2=15.940,P＜0.001);the overall survival time of patients with low lncRNA CRNDE expression (47.50±2.31 months) was significantly prolonged compared with those patients with high expression (32.15±2.19 months),the difference was statistically significant (x2=12.40,P=0.004).Cox multivariate survival analysis also indicated that lncRNA CRNDE expression,distant metastasis,clinical stage were the independent prognostic markers for NSCLC (P＜0.05).Conclusion:lncRNA CRNDE is involved in the occurrence and development of NSCLC,and can be used as a biomarker for the diagnosis and prognosis of non-small cell lung cancer.关键词
lncRNA CRNDE/非小细胞肺癌/生物标志物/临床意义Key words
lncRNA CRNDE/non-small cell lung cancer(NSCLC)/biomarker/clinical significance分类
医药卫生引用本文复制引用
李晓华,田德兴,唐微,但小苹,胡绳,肖贞良..lncRNA CRNDE在非小细胞肺癌组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2017,24(8):889-894,6.基金项目
国家自然科学基金资助项目(NO.81171869).Project supported by the National Natural Science Foundation of China(NO.81171869) （NO.81171869）
