中国耳鼻咽喉头颈外科2017，Vol.24Issue(7)：340-342,3.DOI:10.16066/j.1672-7002.2017.07.004
神经调节肽U在喉癌淋巴结转移中的表达及意义
Significance of neuromedin U expression in lymph node metastasis of laryngocarcinoma
摘要
Abstract
OBJECTIVE To evaluate the effect of neuromedin U(NMU) in lymph node metastasis of laryngocarcinoma and provide a new biomarker of metastasis. METHODS Samples of 120 cases of laryngocarcinoma were collected from the Otolaryngology Department of the First Affiliated Hospital of Jinzhou Medical University from 2013 to 2015. Patients were divided into two groups: metastasis group and non-metastasis group. Immunohistochemistry was performed to analyze the NMU expression in primary tumor and lymph node. An independent tissue microassay was used to analyze the relationship between NMU expression and T, N stages. RESULTS Expression of NMU in metastasis group was higher than that in non-metastasis group, NMU was positively correlated with N stages, but not with T stages. CONCLUSION The expression of NMU is higher in metastasis tissue of laryngocarcinoma, It could be used as a biomarker of lymph node metastasis of laryngocarcinoma.关键词
喉肿瘤/淋巴结/神经调节肽UKey words
Laryngeal Neoplasms/Lymph Nodes/neuromedin U引用本文复制引用
江祺川,陈冬,徐亚男,康健,陈建国..神经调节肽U在喉癌淋巴结转移中的表达及意义[J].中国耳鼻咽喉头颈外科,2017,24(7):340-342,3.基金项目
辽宁省科技厅自然科学基金计划面上项目(201602298) （201602298）
