海南医学院学报2017，Vol.23Issue(15)：2033-2036,4.DOI:10.13210/j.cnki.jhmu.20170810.025
百令胶囊联合常规西医药物对稳定期COPD患者气道重塑进程的影响
Effect of Corbrin Capsule combined with routine western medicine on the airway remodeling process in patients with stable COPD
摘要
Abstract
Objective: To explore the effect of Corbrin Capsule combined with routine western medicine on the airway remodeling process in patients with stable COPD.Methods: A total of 120 patients with stable COPD who were treated in the hospital between May 2014 and December 2016 were collected and divided into control group and observation group according to the random number table method, 60 cases in each group.The control group received routine western medicine treatment, and the observation group received Corbrin Capsule combined with routine western medicine treatment.The differences in serum levels of inflammatory factors, growth factors and fibrosis indexes were compared between the two groups before and after treatment.Results: Before treatment, differences in serum levels of inflammatory factors, growth factors and fibrosis indexes were not statistically significant between the two groups of patients (P>0.05).After 8 weeks of treatment, serum IL-2, IL-4, IL-8, IL-18, VEGF, b-FGF, NGF, LN, HA, PⅢNP and C-Ⅳ levels of both groups of patients were significantly lower than those before treatment (P<0.05), and serum IL-2, IL-4, IL-8, IL-18, VEGF, b-FGF, NGF, LN, HA, PⅢNP and C-Ⅳ levels of observation group were significantly lower than those of control group (P<0.05).Conclusion: Corbrin Capsule combined with routine western medicine treatment can effectively inhibit the fibrosis process in patients with stable COPD.关键词
稳定期慢性阻塞性肺疾病(COPD)/百令胶囊/气道重塑Key words
Stable COPD/Corbrin Capsule/Airway remodeling分类
医药卫生引用本文复制引用
宋素莉..百令胶囊联合常规西医药物对稳定期COPD患者气道重塑进程的影响[J].海南医学院学报,2017,23(15):2033-2036,4.基金项目
北京大学第三医院延庆医院基金项目(2011-7137-01)This project is supported by Yanqing District Hospital of Peking University Third Hospital (grant No.2011-7137-01). （2011-7137-01）
