海南医学院学报2017，Vol.23Issue(15)：2040-2043,4.DOI:10.13210/j.cnki.jhmu.20170809.041
喉癌组织中Six1、MTDH、TKTL1表达量与血清肿瘤标志物含量、细胞增殖活力的相关性
Correlation of Six1, MTDH and TKTL1 expression in laryngeal cancer tissue with serum tumor marker levels and cell proliferation activity
摘要
Abstract
Objective: To study the correlation of Six1, MTDH and TKTL1 expression in laryngeal cancer tissue with serum tumor marker levels and cell proliferation activity.Methods: A total of 48 patients who were diagnosed with primary laryngeal cancer in our hospital were enrolled as observation group, and 50 patients with vocal cord polyp who received laryngoscopy in our hospital during the same period were selected as control group.Fluorescence quantitative PCR was used to determine the expression of Six1, MTDH and TKTL1, and the expression of oncogenes and tumor suppressor genes in lesion tissue of two groups of patients, as well as the contents of tumor markers in serum.Pearson test was used to evaluate the correlation of Six1, MTDH and TKTL1 expression in laryngeal cancer tissue with serum tumor marker levels and cell proliferation activity.Results: Six1, MTDH, TKTL1, c-myc, STAT3 and ras mRNA expression in lesion tissue as well as tumor markers CA72-4, CA19-9, CYFRA21-1, SCC-Ag and TK1 levels in serum of observation group were higher than those of control group, while LKB1, CDKN2 and PTEN mRNA expression were lower than those of control group;Six1, MTDH and TKTL1 expression in laryngeal cancer tissue were positively correlated with serum CA72-4, CA19-9, CYFRA21-1, SCC-Ag and TK1 levels as well as c-myc, STAT3 and ras mRNA expression, and negatively correlated with LKB1, CDKN2 and PTEN mRNA expression.Conclusion: Six1, MTDH and TKTL1 expression increase in laryngeal cancer tissue, and their specific expression are directly correlated with tumor malignancy.关键词
喉癌/Six1/MTDH/TKTL1/肿瘤标志物/细胞增殖Key words
Laryngeal cancer/Six1/MTDH/TKTL1/Tumor marker/Cell proliferation分类
医药卫生引用本文复制引用
彭炜,周明..喉癌组织中Six1、MTDH、TKTL1表达量与血清肿瘤标志物含量、细胞增殖活力的相关性[J].海南医学院学报,2017,23(15):2040-2043,4.基金项目
仙桃市科学技术局2013年指导性科技研究与开发计划项目(2013-1)This study was supported by 2013 Instructional Science and Technology Research and Development Planning Project of Xiantao Science and Technology Bureau (2013-1). （2013-1）
