海南医学院学报2017，Vol.23Issue(15)：2044-2047,4.DOI:10.13210/j.cnki.jhmu.20170810.023
有氧运动训练对AD患者胰岛素抵抗、血脂代谢及炎症反应的影响
Effect of aerobic exercise training on insulin resistance, lipid metabolism and inflammatory response in patients with AD
摘要
Abstract
Objective: To study the effect of aerobic exercise training on insulin resistance, lipid metabolism and inflammatory response in patients with Alzheimer's disease (AD).Methods: A total of 84 patients who were diagnosed with Alzheimer's disease in the Mental Health Center in Zigong City between June 2014 and December 2016 were selected and randomly divided into aerobic exercise group and normal control group who received aerobic exercise intervention combined with conventional drug therapy and conventional drug therapy respectively.The insulin resistance indexes, blood lipid metabolism indexes and inflammatory response indicators were detected before intervention as well as 3 months and 6 months after intervention.Results: Three months and six months after intervention, the HOMA-IR levels as well as serum TC, LDL-C, ApoB, TNF-α, MCP-1, MIA-1α and HMGB1 contents of aerobic exercise group were significantly lower than those before intervention (P<0.05) while HOMA-β, ISIcomp and MBCI levels as well as serum HDL-C and ApoAI contents were significantly higher than those before intervention (P<0.05);the HOMA-IR, HOMA-β, ISIcomp and MBCI levels as well as serum TC, LDL-C, HDL-C, ApoAI, ApoB, TNF-α, MCP-1, MIA-1α and HMGB1 contents of normal control group were not statistically different from those before intervention (P>0.05).Conclusion: Aerobic exercise training can improve insulin resistance and blood lipid metabolism, and inhibit inflammatory response in patients with AD.关键词
阿尔茨海默病/有氧运动/胰岛素抵抗/血脂代谢/炎症反应Key words
Alzheimer's disease/Aerobic exercise/Insulin resistance/Blood lipid metabolism/Inflammatory response分类
医药卫生引用本文复制引用
杨坤芳,谢晓燕,杜昊音,兰利平..有氧运动训练对AD患者胰岛素抵抗、血脂代谢及炎症反应的影响[J].海南医学院学报,2017,23(15):2044-2047,4.基金项目
四川省科技局课题项目(100602)This research project is supported by Science and Technology Bureau of Sichuan Province (grant No.100602). （100602）
