海南医学院学报2017，Vol.23Issue(15)：2048-2051,4.DOI:10.13210/j.cnki.jhmu.20170809.050
糖尿病视网膜病变患者血清炎症因子、脂肪因子及氧化应激指标的变化
Changes of serum inflammatory factors, adipokines and oxidative stress in patients with diabetic retinopathy
摘要
Abstract
Objective: To investigate the changes of serum inflammatory factors, adipokines and oxidative stress in patients with diabetic retinopathy.Methods: A total of 130 patients with type 2 diabetes mellitus admitted to our hospital were selected and divided into 41 cases with diabetic retinopathy (NDR), 44 cases with nonproliferative retinopathy (NPDR) and 45 cases with proliferative retinopathy group (PDR).Besides, 40 healthy volunteers in our hospital were selected as control group (NC).The serum levels of IL-6, TNF-α, hs-CRP, leptin, adiponectin, MDA and SOD were detected.Results: There were significant differences in the levels of IL-6, TNF-α and hs-CRP in groups (P <0.05).The levels of IL-6, TNF-α and hs-CRP in PDR group were (18.19±3.84) pg/mL, (197.48±13.78) ng/L and (8.13±0.74) mg/L, respectively, which were significantly higher than those in NC group, NDR group and NPDR group.The levels of IL-6, TNF-α and hs-CRP in NPDR group were (14.07±3.62) pg/mL, (115.29±20.08) ng/L and (5.62±0.83) mg/L, respectively, which were significantly higher than those in NC and NDR groups.As for these levels in NDR group, they were(12.67±3.93) pg/mL,(89.49±10.49)ng/L and(3.91±0.49)mg/L, respectively, which were significantly higher than those in NC group.The difference was statistically significant(P<0.05).There were significant differences among groups of leptin and adiponectin (P<0.05).The leptin level in PDR group was (23.19±6.48) μg/mL, which was significantly higher than that in NC group, NDR group and NPDR group.However, adiponectin was (3.70±1.02) g/mL, which was lower than those in other three groups.The level of leptin in NPDR group was higher than those in NC group and NDR group while adiponectin was lower than the two groups.Leptin level in NDR group was significantly higher than that in NC group while adiponectin was lower than that in NC group.The differences were statistically significant (P<0.05).Moreover, the levels of MDA and SOD in each group were significantly different (P <0.05).MDA in PDR group was (17.77±4.33) nmol / mL, which was higher than NC group, NDR group and NPDR group, but SOD was (62.35±11.43) U/mL, lower than those in these three groups.MDA in NPDR group was higher than NC group and NDR group but SOD was lower than NC group and NDR group.MDA level in NDR group was higher than that in NC group while SOD in NDR group was lower than that in NC group (P <0.05).Conclusions: Diabetic retinopathy is closely related to inflammatory factors, adipokines and oxidative stress.关键词
糖尿病视网膜病变/炎症因子/脂肪因子/氧化应激Key words
Diabetic retinopathy/Inflammatory factor/Fat factor/Oxidative stress分类
医药卫生引用本文复制引用
努荣古丽·买买提,艾合买提江·吐乎提..糖尿病视网膜病变患者血清炎症因子、脂肪因子及氧化应激指标的变化[J].海南医学院学报,2017,23(15):2048-2051,4.基金项目
新疆维吾尔自治区自然科学基金(2016119D187)It is supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region (No.2016119D187). （2016119D187）
