海南医学院学报2017，Vol.23Issue(15)：2052-2055,4.DOI:10.13210/j.cnki.jhmu.20170726.007
丹红注射液联合厄贝沙坦对糖尿病肾病患者氧化应激反应、肾功能损害的影响
Effect of Danhong injection combined with irbesartan on oxidative stress and renal function damage in patients with diabetic nephropathy
摘要
Abstract
Objective: To study the effect of Danhong injection combined with irbesartan on oxidative stress and renal function damage in patients with diabetic nephropathy.Methods: Patients with diabetic nephropathy who were treated in hospital of Minzu University of China were selected, and random number table was used to divide them into Danhong + ARB group and ARB group who received routine hypoglycemic + Danhong injection + irbesartan therapy and routine hypoglycemic + irbesartan therapy respectively.The serum levels of renal function biochemical indexes, platelet activation indexes and oxidative stress indexes of the two groups of patients were detected before and 6 weeks after treatment.Results: After treatment, serum BUN, Cr, β2-MG, Cys-C, PECAM-1, CD62p, PAC-1, MDA, 8-OHdG and 8-iso-PGF2a levels of both groups of patients were significantly lower than those before treatment while T-AOC, Cu-Zn-SOD, Mn-SOD and GPx-1 levels were significantly higher than those before treatment (P<0.05) and serum BUN, Cr, β2-MG, Cys-C, PECAM-1, CD62p, PAC-1, MDA, 8-OHdG and 8-iso-PGF2a levels of Danhong + ARB group after treatment were significantly lower than those of ARB group while T-AOC, Cu-Zn-SOD, Mn-SOD and GPx-1 levels were significantly higher than those of ARB group.Conclusions: Danhong injection combined with irbesartan therapy for diabetic nephropathy can reduce renal function damage and improve oxidative stress response.关键词
糖尿病肾病/丹红/厄贝沙坦/血小板活化/氧化应激反应Key words
Diabetic nephropathy/Danhong/irbesartan/Platelet activation/Oxidative stress response分类
医药卫生引用本文复制引用
东珍,于秋红,谷晓宁..丹红注射液联合厄贝沙坦对糖尿病肾病患者氧化应激反应、肾功能损害的影响[J].海南医学院学报,2017,23(15):2052-2055,4.基金项目
北京市卫生局专项基金 It is supported by Special Fund of Beijing Health Bureau. （）
