海南医学院学报2017，Vol.23Issue(15)：2075-2077,2081,4.DOI:10.13210/j.cnki.jhmu.20170810.027
枸地氯雷他定联合布地奈德混悬液对行鼻窦内窥镜手术CRS患者血清IgE、EOS和炎性因子的影响
Effects of Desloratadine Citrate Disodium combined with Budesonide Nasal Spray on serum IgE, EOS and inflammatory factors in patients with CRS after endoscopic sinus surgery
摘要
Abstract
Objective: To observe the clinical application of Desloratadine Citrate Disodium combined with Budesonide Nasal Spray in patients with CRS after endoscopic sinus surgery, and to analyze the changes of serum immunoglobulin E (IgE), eosinophils (EOS) and inflammatory factors in patients.Methods: A total of 90 patients with CRS who received endoscopic sinus surgery were randomly divided into control group (n =45) and observation group (n =45) according to the lottery method.The patients in the control group were treated with the Budesonide Nasal Spray, while those who were in the observation group were treated with Desloratadine Citrate Disodium combined with Budesonide Nasal Spray.The changes of serum IgE, EOS and inflammatory factors were measured before and after operation in all subjects.Results: Before treatment, there was no significant difference in IgE and EOS levels between the control group and the observation group (P>0.05), while after treatment, the levels of serum IgE and EOS in the two groups were significantly lower than those before treatment (P<0.05), and the levels of serum IgE and EOS of the observation group were significantly lower than those of the control group (P<0.05).Before treatment, there was no significant difference in the level of inflammatory factors between the control group and the observation group (P>0.05), while after treatment, the levels of serum IL-6, IL-8, TNF-α and hs-CRP were significantly lower than those before treatment (P<0.05) and the levels of serum IL-6, IL-8, TNF-α and hs-CRP in the observation group were significantly lower than those of the control group (P<0.05).Conclusions: Based on endoscopic sinus surgery and Budesonide Nasal Spray treatment, combinations of Desloratadine Citrate Disodium treatment for CRS patients can reduce the serum IgE and EOS levels and decrease the inflammatory response.Therefore, it is a potential effective treatment for patients with CRS.关键词
枸地氯雷他定/布地奈德混悬液/鼻窦内窥镜手术/慢性鼻-鼻窦炎Key words
Desloratadine Citrate Disodium/Budesonide nasal spray/Endoscopic sinus surgery/Chronic rhinosinusitis分类
医药卫生引用本文复制引用
毕梦,王丛,杨飞..枸地氯雷他定联合布地奈德混悬液对行鼻窦内窥镜手术CRS患者血清IgE、EOS和炎性因子的影响[J].海南医学院学报,2017,23(15):2075-2077,2081,4.基金项目
四川省卫生厅科研项目(100308)This study was supported by Research Project of Sichuan Provincial Health Bureau (Grant No.100308) （100308）
