海南医学院学报2017，Vol.23Issue(15)：2078-2081,4.DOI:10.13210/j.cnki.jhmu.20170810.026
瑞芬太尼联合丙泊酚麻醉对脑外科手术患者IL-1β、IL-6、TNF-α及血流动力学的影响
Effects of remifentanil combined with propofol anesthesia on IL-1β, IL-6, TNF-α and hemodynamics in patients undergoing brain surgery
摘要
Abstract
Objective: To observe the clinical application of remifentanil combined with propofol anesthesia and fentanyl combined with propofol anesthesia in patients with brain surgery, and to analyze the hemodynamics and serum IL-1β, IL-6 and TNF-α before and after operation.Methods: A total of 90 patients with brain surgery were randomly divided into control group (n=45) and observation group (n=45).All patients were given the same anesthesia combined with drugs.The control group was given fentanyl and the observation group was given remifentanil.Hemodynamics and inflammatory parameters were measured before and after surgery in all subjects.Results: There were no significant differences in the hemodynamic indexes between the two groups (P>0.05).At T2, T3 and T4, the heart rate (HR) and mean arterial pressure (MAP) of the observation group were significantly lower than those of the control group, and the blood oxygen saturation (SpO2) was significantly higher than that of the control group (P<0.05).At T2, T3 and T4, the HR and MAP of the control group were significantly higher than those of T1, while SpO2 was significantly lower than T1 (P<0.05).There was no significant difference in HR, MAP and SpO2 between the observation group at T1, T2, T3 and T4 (P>0.05).There were no significant differences in serum IL-1β, IL-6 and TNF-α levels between the control group and the observation group before surgery (P>0.05).After 24 h of operation, the levels of IL-1β, IL-6 and TNF-α in the two groups were higher than those before operation (P<0.05).The levels of IL-1β, IL-6 and TNF-α in the observation group were significantly lower than those in the control group at 24 h after the operation (P<0.05).Conclusion: Remifentanil combined with propofol anesthesia can maintain the hemodynamic stability and reduce the concentration of inflammatory factors, which is one of the potential effective anesthetic compounds.关键词
瑞芬太尼/丙泊酚/脑外科手术/炎性因子/血流动力学Key words
Remifentanil/Propofol/Brain surgery/Inflammatory factor/Hemodynamics分类
医药卫生引用本文复制引用
沈倩,彭坚,施媛,杨镭镭..瑞芬太尼联合丙泊酚麻醉对脑外科手术患者IL-1β、IL-6、TNF-α及血流动力学的影响[J].海南医学院学报,2017,23(15):2078-2081,4.基金项目
武汉市科技引导计划(20161232988-02)This study is supported by Science and Technology Guidance Plan of Wuhan (20161232988-02). （20161232988-02）
