海南医学院学报2017，Vol.23Issue(15)：2138-2141,4.DOI:10.13210/j.cnki.jhmu.20170810.029
烧伤脓毒症患儿血浆肾上腺髓质素前体及皮质醇水平与全身炎症反应及靶器官损伤的关系
Relationship of plasma proadrenomedullin and cortisol levels with systemic inflammatory response and target organ damage in children with sepsis after burn
摘要
Abstract
Objective: To study the relationship of plasma proadrenomedullin (pro-ADM) and cortisol (Cor) levels with systemic inflammatory response and target organ damage in children with sepsis after burn.Methods: A total of 30 children with sepsis after burn who were treated in the hospital between August 2014 and August 2016 were collected as observation group, and 30 normal children who received vaccination in the hospital during the same period were collected as normal control group.The pro-ADM and Cor levels in plasma as well as the levels of inflammatory factors, myocardial injury markers and intestinal barrier function indexes in serum of the two groups were determined.Pearson test was used to assess the correlation of plasma pro-ADM and Cor levels with systemic inflammatory response and target organ damage in patients with sepsis after burn.Results: Plasma pro-ADM and Cor levels in observation group were significantly higher than those in normal control group (P<0.05).Serum inflammatory cytokines IL-1, IL-6, IL-10 and TNF-α levels in observation group were higher than those in normal control group;serum myocardial injury markers CK-MB, cTnⅠand NT-proBNP levels were higher than those in normal control group;serum intestinal barrier function indexes ET, DAO and D-L levels were significantly higher than those in normal control group (P<0.05).Conclusion: Plasma pro-ADM and Cor levels increase in patients with sepsis after burn, and are highly consistent with systemic inflammatory response and target organ injury.关键词
脓毒症/肾上腺髓质素前体/皮质醇/全身炎症反应/靶器官损伤Key words
Sepsis/Proadrenomedullin/Cortisol/Systemic inflammatory response/Target organ injury分类
医药卫生引用本文复制引用
魏星,欧阳杰,周臣..烧伤脓毒症患儿血浆肾上腺髓质素前体及皮质醇水平与全身炎症反应及靶器官损伤的关系[J].海南医学院学报,2017,23(15):2138-2141,4.基金项目
云南省教育厅科学研究项目(2013C152)This study is supported by Scientific Research Project of Education Department in Yunnan Province (grant No.2013C152). （2013C152）
