海南医学院学报2017，Vol.23Issue(15)：2153-2156,4.DOI:10.13210/j.cnki.jhmu.20170810.017
前列腺癌病灶内GPRC6A、PKCzeta表达与细胞增殖、EMT的关系研究
Relations of GPRC6A and PKCzeta expression levels in prostate cancer lesions with cell proliferation and EMT
摘要
Abstract
Objective: To study the relations of GPRC6A and PKCzeta expression levels in prostate cancer lesions with cell proliferation and epithelial-mesenchymal transition (EMT).Methods: Patients with prostate cancer and patients with benign prostatic hyperplasia who received surgical resection in the Third People's Hospital of Huizhou City between June 2014 and March 2017 were selected as the research subjects.Prostate cancer lesion and the lesion adjacent to carcinoma were properly collected from patients with prostate cancer, and then the expression of GPRC6A, PKCzeta, cell proliferation genes and EMT genes in these lesions were detected.Results: GPRC6A, Survivin, SRSF1, Bcl-xl, N-cadherin and Vimentin expression in prostate cancer lesions and adjacent lesions were significantly higher than those in benign prostatic hyperplasia lesions (P<0.05) while PKCzeta, Caspase-3, Caspase-9, Apaf-1, E-cadherin and CK5/6 expression were significantly lower than those in benign prostatic hyperplasia lesions (P<0.05);Survivin, SRSF1 and Bcl-xl expression in prostate cancer lesions with lower PKCzeta expression were significantly higher than those in prostate cancer lesions with higher PKCzeta expression (P<0.05) while Caspase-3, Caspase-9 and Apaf-1 expression were significantly lower than those in prostate cancer lesions with higher PKCzeta expression (P<0.05);E-cadherin and CK5/6 expression in prostate cancer lesions with lower GPRC6A expression were significantly higher than those in prostate cancer lesions with higher GPRC6A expression (P<0.05) while N-cadherin and Vimentin expression were significantly lower than those in prostate cancer lesions with higher GPRC6A expression (P<0.05).Conclusions: Highly expressed GPRC6A and lowly expressed PKCzeta in prostate cancer lesions can promote cell EMT and proliferation respectively.关键词
前列腺癌/G蛋白偶联受体C6A/蛋白激酶Cζ/增殖/上皮间质转化Key words
Prostate cancer/G-protein-coupled receptor C6A/Protein kinase Cζ/Proliferation/Epithelial-mesenchymal transition分类
医药卫生引用本文复制引用
曾繁飞,田生平,杨伟忠,张小悦..前列腺癌病灶内GPRC6A、PKCzeta表达与细胞增殖、EMT的关系研究[J].海南医学院学报,2017,23(15):2153-2156,4.基金项目
惠州市科技计划项目 (2016Y154)This study was supported by Huizhou Municipal Science and Technology Project (Grant No.2016Y154) （2016Y154）
