河北医学2017，Vol.23Issue(8)：1233-1236,4.DOI:10.3969/j.issn.1006-6233.2017.08.001
结直肠癌MICA基因的表达与p53K-ras基因突变的关系研究
The Relationship between MICA Gene Expression of Bladder Cancer and Mutation of p53 and K-ras Gene
摘要
Abstract
Objective:To investigate the relationship between the expression of MICA gene in bladder cancer and the mutation of p53 gene and K-ras gene.Methods: 66 cases of bladder cancer patients with clinical data in our hospital from March 2014 to March 2016 were analyzed.Semi quantitative PCR-SSCP technique was used to detect the expression of MDR1 gene and p53 and K-ras in cancer tissues,and analyzed the relationship between the expression of MICA gene in colorectal cancer and the mutation of p53 and K-ras genes.Results: The study found that there was no correlation between the expression of MICA and the location,age and sex of the patients with colorectal cancer(P > 0.05).In 66 patients,the mean expression of MICA in 22 lymph node metastasis patients was higher than that without lymph node metastasis,and the difference was statistically significant(P < 0.05).8 cases of K-ras and p53 gene expression of the MICA gene mutation combined with average weight is higher than non mutation,the difference was statistically significant(P < 0.05),12 cases of K-ras gene mutation MICA average expression was slightly higher than that without mutation,but the difference was not statistically significant(P > 0.05),16 cases of p53 gene mutation MICA expression was significantly better than the average mutation in the p53 gene,the difference was statistically significant(P < 0.05).Conclusion: The high expression of MICA gene has become a key indicator for the detection of bladder cancer,and the correlation between K-ras and p53 gene and its high expression.关键词
MICA基因/K-ras基因/p53基因/结直肠癌Key words
MICA gene/K-ras gene/p53 gene/Bladder cancer引用本文复制引用
谷敬锋,王桂琦,刘海霞,高英超,王园园..结直肠癌MICA基因的表达与p53K-ras基因突变的关系研究[J].河北医学,2017,23(8):1233-1236,4.基金项目
河北省卫计委资助项目,(编号20160203) （编号20160203）
