解放军医学院学报2017，Vol.38Issue(8)：716-718,723,4.DOI:10.3969/j.issn.2095-5227.2017.08.002
依折麦布联合阿托伐他汀类对低密度脂蛋白胆固醇未达标的急性冠脉综合征患者胆固醇代谢的影响
Effect of atorvastatin plus ezetimibe therapy on serum cholesterol synthesis and absorption metabolism in acute coronary syndrome patients not achieving LDL-C goal
摘要
Abstract
Objective To investigate the effects of atorvastatin combined with ezetimibe on serum cholesterol synthesis and absorption in acute coronary syndrome patients not achieving LDL-C goal.Methods Eighty ACS patients not achieving LDL-C goal in our hospital from June 2012 to June 2014 were randomly divided into atorvastatin plus ezetimibe group (n=42,atorvastatin 20 mg/d plus ezetimibe 10 mg/d) and atorvastatin double-dose group (n=38,atorvastatin 40 mg/d).Serum cholesterol synthesis and absorption markers were measured before and after 12-week treatment.Results After 12 weeks,the serum LDL-C level was significantly lower in atorvastatin plus ezetimibe group than that in double dose atorvastatin group [(1.81 ± 0.38) mmol/L vs (2.01 ± 0.43) mmol/L,P ＜ 0.05].Serum cholesterol synthesis markers (lathosterol,24-dehydrogenation) decreased after 12-week treatment in the two groups,particularly in double dose atorvastatin group.Cholesterol absorption markers (campesterol,stigmasterol,sitosterol) decreased in atorvastatin plus ezetimibe group after 12-week treatment (P ＜ 0.05,respectively).However,they increased in the double dose atorvastatin group.Conclusion Atorvastatin combined with ezetimibe reduce cholesterol synthesis and absorption markers at the same time in acute coronary syndrome patients not achieving LDL-C goal.关键词
急性冠脉综合征/胆固醇/7烯胆甾醇/24-脱氢胆甾烷醇/油菜甾醇/豆固醇/谷甾醇Key words
acute coronary syndrome/cholesterol/7-lathosterol/24-dehydrogenation/campesterol/stigmasterol/sitosterol分类
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刘杰,薛浩,耿晓雯,张威,朱航..依折麦布联合阿托伐他汀类对低密度脂蛋白胆固醇未达标的急性冠脉综合征患者胆固醇代谢的影响[J].解放军医学院学报,2017,38(8):716-718,723,4.基金项目
中华医学会临床科研专项资金项目基金(14010080545)Supported by the Clinical Special Research Grant of Chinese Medical Association(14010080545) （14010080545）
