解放军医学院学报2017，Vol.38Issue(8)：719-723,5.DOI:10.3969/j.issn.2095-5227.2017.08.003
替吉奥+奥沙利铂新辅助化疗联合胃癌根治术治疗老年进展期胃癌的疗效观察
Effectiveness and safety of SOX regimen as neoadjuvant chemotherapy combined with D1 +surgery for advanced gastric cancer in elderly patients
摘要
Abstract
Objective To investigate the effectiveness and safety of SOX regimen combined with D1+ surgery for advanced gastric cancer in elderly patients.Methods Clinical data about elderly gastric cancer patients (≥ 60 years) admitted to our hospital from January 2013 to December 2015 were retrospectively analyzed.Sixty-four patients who underwent SOX regimen combined with D1+ surgery and 64 patients who underwent D2 surgery were randomly selected in a case-control study.Results The baseline data was well matched in both two groups.The disease control rate and overall response rate of SOX neoadjuvant chemotherapy were 98.44％ and 70.31％ respectively.Occurrence rates of both grade 3 hematological and non-hematological toxicities were 6.25％,respectively.Compared to D2 surgery,SOX neoadjuvant chemotherapy combined with D1+ surgery had the advantage of shorter operative time (206.72 ± 50.29 min vs 225.81 ± 50.75 min,t=1.913,P=0.034),shorter postoperative ICU stay (21.23 ± 3.56 h vs 33.97 ± 4.43 h,t=3.355,P=-0.044),less operative blood loss (241.41 ± 48.99 ml vs 290.63 ± 41.95 ml,t=2.138,P=0.048),and less surgical related complications (9.38％ vs 21.88％,x 2=3.793,P=0.048).In addition,the median overall survival was not significantly different between SOX neoadjuvant chemotherapy combined with D1+ surgery group and D2 surgery group in elderly patients with advanced gastric cancer.Conclusion SOX regimen as neoadjuvant chemotherapy combined with D1+ surgery is associated with high efficacy and safety in elderly advanced gastric cancer patients.关键词
进展期胃癌/老年人/新辅助化疗/胃癌根治术Key words
advanced gastric cancer/aged/neoadjuvant chemotherapy/gastrectomy分类
医药卫生引用本文复制引用
吴晓松,梁文全,崔建新,郗洪庆,陈凛..替吉奥+奥沙利铂新辅助化疗联合胃癌根治术治疗老年进展期胃癌的疗效观察[J].解放军医学院学报,2017,38(8):719-723,5.基金项目
部委级资助项目 （）
军队保健专项科研课题项目(15BJZ40)Supported by the Special Research Projects on Health Care of PLA(15BJZ40) （15BJZ40）
