昆明医科大学学报2017，Vol.38Issue(8)：35-39,5.
趋化因子受体CX3CR1基因T280M多态性在云南彝族人群中的分布
The T280M Polymorphisms of Fractalkine Receptor CX3CR1 in a Yi Nationality Population of Yunnan Province
摘要
Abstract
Objective To investigate the distribution of the CX3CR1 gene T280M polymorphism in a Yi nationality population of Yunnan province,and lay the foundation of exploring the pathogenesis of CX3CR1 gene ralated diseases.Methods We studied 268 healthy individuals of Yi nationality in a rural area of Jinning,Yunnan province.Genotype determination of the CX3CR1 gene T280M polymorphism was performed using Polymerase Chain Reaction- Restriction fragment Length Polymorphism(PCR- RFLP)technique.The frequencies of MM, MT,TT genotypes and M,T alleles were calculated. We conducted some analysis by comparing with results of other populations collected from previous studies.Results In the healthy Yi nationality population of Yunnan province,CX3CR1 genotype frequencies for the MM,MT and TT genotypes were 1.12%,11.94% and 86.94%. Deriving from those,the allele frequencies for the M and T allele were 7.09% and 92.91% respectively.Significant differences in the distribution of CX3CR1 genotypes and the allele frequencies were observed between the Yunnan Yi people and other nationality populations(The han,The uighurs,Greece,France,Serbia,India,Italy and The Caucasus)(P<0.05);whereas there was no significant difference with the Jingpo nationality(P>0.05). Conclusions Differences of the genotype or allele frequency of the CX3CR1 T280M polymorphism exist in different nationalities and different races,and the national difference is more obvious than ethnic ones.关键词
CX3CR1基因/基因多态性/彝族/分布Key words
CX3CR1 gene/Genetic polymorphism/Yi nationality/Distribution分类
医药卫生引用本文复制引用
陈志彬,莫艳萍,杨钰,陈灿昆,杨靖宜,万瑞雪,范志祥,龙莉..趋化因子受体CX3CR1基因T280M多态性在云南彝族人群中的分布[J].昆明医科大学学报,2017,38(8):35-39,5.基金项目
国家自然科学基金资助项目(81160164) （81160164）
云南省自然科学基金资助项目(2008CD117) （2008CD117）
昆明医科大学大学生创新性实验计划基金资助项目(昆医大〔2017〕 2号) （昆医大〔2017〕 2号）
