昆明医科大学学报2017，Vol.38Issue(8)：40-43,4.
麻芎舒痛方治疗偏头痛的临床效果及对血清5-HT、NF-κB和炎症因子水平的影响
Effect of Ma Xiong Shu Tong Fang on Migraine and Its Influence on Serum Levels of 5-HT,NF-NF-κB and Inflamatory Cytokines
摘要
Abstract
Objective To study the safety and effectiveness of Ma Xiong Shu Tong Fang for migraine and evaluate the white matter lesions(WML)by brain MRI.MethodsA total of 122 consecutives were randomly divided into control and observation groups and each group had 61 cases.The patients in control group received Flunarizine Hydrochloride Capsules 10 mg/d,and the patients in observation group adopted Ma Xiong Shu Tong Fang three particles per day,and the course was four weeks. Then we compared TCM syndrome integrals,total effective rate and incidence of adverse reactions,serum 5- HT,NF-κB,IL-6 and TNF-αlevels,positive rate and degrees of WML by MRI.Results The TCM syndrome integrals after treatment in observation group was significantly lower than control group(P<0.05). There were no severe complications in the two groups. The serum 5- HT,NF-κB,IL-6 and TNF-αlevels in observation group were all lower,positive rate of WML was also lower(P<0.05).Conclusion Ma Xiong Shu Tong Fang is safe and effective for mgraine,it can reduce serum levels of 5- HT,NF-κB,IL-6 and TNF-αand improve WML.关键词
麻芎舒痛方/偏头痛/脑白质病变/5-羟色胺/NF-κB/IL-6Key words
Ma Xiong Shu Tong Fang/Migraine/White matter lesions/5- HT/NF-κB/IL-6分类
医药卫生引用本文复制引用
张金培,杨屹,靳艳..麻芎舒痛方治疗偏头痛的临床效果及对血清5-HT、NF-κB和炎症因子水平的影响[J].昆明医科大学学报,2017,38(8):40-43,4.基金项目
国家自然科学基金资助项目(81470188) （81470188）
