临床肝胆病杂志2017，Vol.33Issue(8)：1415-1418,4.DOI:10.3969/j.issn.1001-5256.2017.08.002
慢性乙型肝炎抗病毒治疗的挑战与策略——如何实现临床治愈最大化
Challenges and strategies of antiviral therapy for chronic hepatitis B-how to achieve the maximization of clinical cure ?
摘要
Abstract
Hepatitis B virus infection is still a major public health issue in the world,and antiviral therapy is the key therapeutic regimen to delay disease progression and improve outcome in patients with chronic hepatitis B (CHB).Various international guidelines recommend nucleos(t) ide analogues (NAs) and long-acting interferon as the first-line antiviral therapy.However,long-term administration of NAs has the disadvantages of long course of treatment,low HBeAg seroconversion rate,extremely low HBsAg clearance or seroconversion rate,low safety,and drug resistance.Therefore,it is an important issue to increase the seroconversion rates of HBeAg and HBsAg in treatment-experienced patients and realize clinical cure in the treatment of CHB.In recent years,many global randomized clinical trials including OSST,Switch,and ARES have shown that a combination of NAs and PEG-IFN or sequential therapy with NAs and PEG-IFN can increase the seroconversion rates of HBeAg and HBsAg in CHB patients and realize clinical cure,which provides a new direction for NAs in the treatment of CHB patients.关键词
肝炎,乙型,慢性/抗病毒药/核酸类,核苷酸类和核苷类/干扰素类/述评Key words
hepatitis B, chronic/antiviral agents/nucleic acids, nucleotides, and nucleosides/interferons/editorial分类
医药卫生引用本文复制引用
王伟静,谢青..慢性乙型肝炎抗病毒治疗的挑战与策略——如何实现临床治愈最大化[J].临床肝胆病杂志,2017,33(8):1415-1418,4.基金项目
上海市公共卫生三年行动计划(15GWZK0102) （15GWZK0102）
上海市级医院临床技能与临床创新三年行动计划(16CR1002A) （16CR1002A）
