临床肝胆病杂志2017，Vol.33Issue(8)：1458-1464,7.DOI:10.3969/j.issn.1001-5256.2017.08.009
HBV感染与复制模型的建立及应用
Establishment and application of in vitro and in vivo models of hepatitis B virus infection
摘要
Abstract
Hepatitis B is still an important infectious disease which threatens human health,and current antiviral therapy,including interferon and nucleos(t) ide analogues,cannot cure chronic hepatitis B.Therefore,it is urgent to explore the detail mechanisms of HBV replication and pathogenesis,identify new therapeutic targets,and develop new drugs or treatment regimens,which relies on the development of suitable models for HBV infection and replication.Species restriction and tissue tropism of HBV have limited the development of models for HBV infection and replication.With the support by National Science and Technology Major Project for Infectious Diseases,the researchers in China have developed a series of cellular and animal models for HBV.This article reviews these models with reference to recent research advances in China and foreign countries.关键词
肝炎病毒,乙型/细胞模型/疾病模型,动物Key words
hepatitis B virus/cell model/disease models, animal分类
医药卫生引用本文复制引用
王宝菊,朱彬,郭伟娜,杨东亮..HBV感染与复制模型的建立及应用[J].临床肝胆病杂志,2017,33(8):1458-1464,7.基金项目
国家传染病科技重大专项(2008ZX10002011,2012ZX10004503) （2008ZX10002011,2012ZX10004503）
国家自然科学基金(81001313,81101248,81371828,81461130019) （81001313,81101248,81371828,81461130019）
国家国际科技合作计划(2011DFA31030) （2011DFA31030）
国家科技支撑计划课题(2015BAI09B06) （2015BAI09B06）
德国科学基金会德中跨学科重大合作项目(TRR60) （TRR60）
