临床肝胆病杂志2017，Vol.33Issue(8)：1595-1598,4.DOI:10.3969/j.issn.1001-5256.2017.08.040
高尔基体蛋白73与肝脏疾病的关系
Research advances in association between Golgi protein 73 and liver diseases
摘要
Abstract
Golgi protein 73 (GP73) has a very low expression level in normal people,while it has a significantly higher expression level in patients with liver diseases and hepatocellular carcinoma (HCC),and therefore,it may become a new marker for HCC.This article introduces the distribution of GP73 in human body and definitions of different subtypes of GP73 and elaborates on its association with benign/malignant liver diseases and surgical operation based on the subtypes of GP73,as well as the application of GP73 in the differentiation of benign/malignant liver diseases.Since GP73 is closely associated with the development,progression,and prognosis of liver diseases,this article summarizes the latest advances in basic research,introduces the structural basis of fucosylated GP73 and proliferation,migration,and invasion of hepatoma cells and known signaling pathways,and lists the factors which affect the expression of GP73.关键词
高尔基体蛋白73/肝疾病/早期诊断/综述Key words
golgi protein 73/liver diseases/early diagnosis/review分类
医药卫生引用本文复制引用
魏丰贤,刘钊,耿婕,苏国宏,陈默,王满才,曹维嘉,张有成..高尔基体蛋白73与肝脏疾病的关系[J].临床肝胆病杂志,2017,33(8):1595-1598,4.基金项目
甘肃省消化系肿瘤重点实验室开放课题(lzujbky-2011-t03-04) （lzujbky-2011-t03-04）
