林产化学与工业2017，Vol.37Issue(4)：35-39,5.DOI:10.3969/j.issn.0253-2417.2017.04.005
异海松基水杨酰腙的合成及细胞毒性评价
Synthesis and Cytotoxicity of Isopimaric-based Salicyloylhydrazone
摘要
Abstract
Isopimaric-based salicylhydrazone was synthesized by the reaction of isopimaric acid(IPA)and salicylaldehyde,and characterized by IR,1H NMR and HRMS.The cytotoxicities of target compound were evaluated against two human cancer cells(hepatoma cell HepG-2 and prostatic carcinoma cell PC-3)and a human normal liver cell L-02 in vitro using MTT method,which were compared with that of the positive drug taxol.The results showed that cytotoxic activity of isopimaric-based salicylhydrazone was similar or higher than that of taxol(IC50,12.14 and 6.48 μmol/L)against HepG-2 and PC-3 cell lines,with IC50 values 6.50 and 9.25 μmol/L,respectively.Moreover,isopimaric-based salicylhydrazone displayed hypotoxicity to L-02 cell,with IC50 value 68.01 μmol/L,which was much lower than that of taxol(IC50,4.02 μmol/L).The inhibitory rates and cell morphological changes showed that isopimaric-based salicylhydrazone significantly inhibited the cell proliferation in a dose-dependent manner.关键词
酰腙/异海松酸/异海松基水杨酰腙/细胞毒性Key words
acylhydrazone/isopimaric acid/isopimaric-based salicyloylhydrazone/cytotoxic分类
化学化工引用本文复制引用
刘娟娟,卢言菊,陈玉湘,赵振东..异海松基水杨酰腙的合成及细胞毒性评价[J].林产化学与工业,2017,37(4):35-39,5.基金项目
中国林科院中央级公益性科研院所基本科研业务费专项资金(CAFYBB2017QA018) （CAFYBB2017QA018）
国家自然科学基金资助项目(31370575) （31370575）
