临床神经病学杂志2017，Vol.30Issue(4)：251-255,270,6.
帕金森病患者静息态脑功能局部一致性研究
Study of regional homogeneity of rest-state brain function in patients with Parkinson's disease
摘要
Abstract
Objective To explore the changes of regional homogeneity (ReHo) of rest-state brain function in patients with Parkinson's disease (PD). Methods Rest-state functional magnetic resonance imaging (fMRI) were checked in 22 PD patients (PD group) and 22 normal controls (normal control group), the results were analyzed. Correlation analysis of ReHo between PD in the on state and off state versus the left finger opposition task improvement ratio of the PD was performed. Results Compared with normal control group, brain region of ReHo values decreased in "off" time of PD group was left putamen and bilateral cerebellum, and brain region increased in right thalamus, left middle frontal gyrus, left premotor area, inferior parietal lobule, right postcentral gyrus, bilateral supplementary area and bilateral praecuneus. ReHo values of bilateral cerebellum, right inferior temporal gyrus, right putamen, right praecuneus, right thalamus and bilateral supplementary area in PD group at "on" time were significantly increased than those at "off" time; and right cerebellum posterior lobe, right middle temporal gyrus, right superior temporal gyrus, left middle frontal gyrus, lift superior frontal gyrus and right posterior cingulate gyrus in PD group at "on" time were significantly decreased than those at "off" time. The improvement rate of the left finger opposition task in PD patient was 1. 59% - 126. 67%, average (54. 15 ± 38． 02)%. Pearson correlation analysis showed that the right thalamus ReHo of PD was positive correlated with their improvement rate of the left finger opposition task(r = 0． 637,P < 0． 01). Conclusions The resting state brain function of PD patients is extensively abnormal. L-dopa may normalize aberrant functional circuits in PD. As an important node of the motor circuits, the function and metabolize of the neurons in thalamus has been changed in PD patients.关键词
帕金森病/局部一致性/静息态功能磁共振Key words
Parkinson's disease/ regional homogeneity/ rest-state functional MRI分类
医药卫生引用本文复制引用
闫磊,刘卫国,胡晓,宋潇鹏,祝雅静,孙佳男..帕金森病患者静息态脑功能局部一致性研究[J].临床神经病学杂志,2017,30(4):251-255,270,6.基金项目
国家自然科学基金项目(81571348) （81571348）
江苏省自然科学基金(SBK2015022028) （SBK2015022028）
南京市卫生局计划项目(201402017) （201402017）
