南京医科大学学报（自然科学版）2017，Vol.37Issue(8)：1010-1014,5.DOI:10.7655/NYDXBNS20170818
术前血清CA19-9阳性和AFP阳性的胃癌患者临床病理研究
Analysis of clinicopathological characteristics of gastric cancer patients with serum CA19-9-positive and AFP-positive perioperatively
摘要
Abstract
Objective:To evaluate the clinicopathological characteristics of gastric cancer patients with perioperative serum carbohydrate antigen 19-9 (CA19-9)-positive and alpha-fetoprotein (AFP)-positive,and combined effect of perioperative serum CA19-9 and AFP on clinicopathological characteristics of gastric cancer patients.Methods:The clinicopathological characteristics of 900 gastric cancer patients with serum CA19-9 and AFP detection perioperatively from the First Affiliated Hospital of NJMU were analyzed retrospectively.Results:Patients with elevated serum CA19-9 had the characteristics of more advanced T stage (T4 stage,94.2％ vs.65.5％),later clinical stage (Ⅲ+Ⅳstage,89.2％ vs.61.5％),more common lymph node metastasis (81.5％ vs.59.1％) and more remarkable vascular as well as neural invasion compared with those with normal level of serum CA19-9 (32.5％ vs.23.3％;42.5％ vs.27.1％);Compared with AFP-negative patients,the AFP-positive patients suffered later clinical stage (Ⅲ +Ⅳ stage,88.9％ vs.60.6％),more common lymph node metastasis (81.5％ vs.59.1％) and more marked neural invasion (44.4％ vs.27.0％) (P＜0.05).Patients with one or two positive tumor markers suffered more advanced T stage,later clinical stage,more common lymph node metastasis and more remarkable vascular as well as neural invasion compared with those with double-negative tumor markers (P＜0.05).Two-category logistic regression analysis showed that CA19-9 (+) was the independent risk factor for GC T stage;compared with CA19-9 (-)-AFP (-),CA19-9(+)-AFP(+) was the independent risk factor for GC vascular invasion,CA19-9(+)-AFP(-) was the independent risk factor for GC T stage (P＜0.05).Conclusion:Perioperative serum levels of CA19-9 and AFP are closely correlated with clinicopathological features for patients with gastric cancer,and the two tumor markers are highly recommended detecting perioperatively for offering information of clinicopathological characteristics.关键词
糖链抗原19-9/甲胎蛋白/胃癌Key words
carbohydrate antigen 19-9/alpha-fetoprotein/gastric cancer分类
医药卫生引用本文复制引用
韩建波,骆大葵,杨力,黄驰,还向坤,王悠南,徐泽宽..术前血清CA19-9阳性和AFP阳性的胃癌患者临床病理研究[J].南京医科大学学报（自然科学版）,2017,37(8):1010-1014,5.基金项目
江苏省“科教兴卫”工程医学重点人才培养项目(RC201159) （RC201159）
江苏省自然科学基金(BK20131447) （BK20131447）
江苏省“333高层次人才培养工程”(BRA2013280) （BRA2013280）
江苏高校优势学科建设工程(IX10231801) （IX10231801）
