山东中医药大学学报2017，Vol.41Issue(5)：482-485,4.
氧化苦参碱磷脂复合物肠溶缓释胶囊在小鼠体内的药代动力学及相对生物利用度研究
Study on the Pharmacokinetics and Relative Bioavailability of Enteric Sustained-release Capsule of Oxymatrine Phospholipid Complex in Mice
摘要
Abstract
Objective:To study the pharmacokinetics and relative bioavailability of enteric sustained-release capsule of oxymatrine phospholipid complex in mice. Methods:Total 84 healthy Kunming mice were random-ly divided into two groups,the blood was collected within the specified time. Serum levels were determined by HPLC after gavage oxidation of matrine and enteric sustained-release capsule of oxymatrine phospholipid contents. PKSolver 2 pharmacokinetic software was fitted to the curve ,and the pharmacokinetic parameters were calculated according to the single compartment model of the oral absorption. Results:After given oxi-dation of matrine and enteric sustained-release capsule of Oxymatrine phospholipid complex content ,concen-tration-time curve accorded with one compartment model of oral absorption. The time for peak concentration in oxidation of matrine and enteric sustained-release capsule of Oxymatrine phospholipid complex was Tmax (1.14±0.17) h and (1.91±0.22) h and the peak concentration was Cmax(2.59±0.07)μg/mL and (3.48± 0.87)μg/mL,AUC (8.11±1.24)μg/mL·h and (17.46±2.16)μg/mL·h respectively. Conclusion:The relative bioavailability of enteric sustained-release capsule of oxymatrine phospholipid complex was 215.29%,improv-ing the bioavailability significantly.关键词
氧化苦参碱/肠溶缓释/药代动力学/生物利用度Key words
oxymatrine/enteric controlled release/pharmacokinetics/bioavailability分类
医药卫生引用本文复制引用
郭辉,陈新梅,段章好..氧化苦参碱磷脂复合物肠溶缓释胶囊在小鼠体内的药代动力学及相对生物利用度研究[J].山东中医药大学学报,2017,41(5):482-485,4.基金项目
山东省高校中医药抗病毒协同创新中心课题(编号:XTCX2014C02-05) （编号:XTCX2014C02-05）
