山东医药2017，Vol.57Issue(33)：5-8,4.DOI:10.3969/j.issn.1002-266X.2017.33.002
2型糖尿病合并不同分级高血压患者血清Giα-2、NGAL水平变化及意义
Changes in levels of serum Giα-2 and NGAL in type 2 diabetes combined with different classifications of hypertension
摘要
Abstract
Objective To investigate the changes of serum inhibitory G-protein subunit Gi α-2 (Giα-2) and neutrophil gelatinase-associated lipocalin (NGAL) in type 2 diabetes combined with different classifications of hypertension and its clinical value.Methods Totally 197 patients with type 2 diabetes were selected.They were divided into 45 cases of simple diabetes (DS group), 47 cases of type 2 diabetes combined with grade 1 hypertension (DH1 group), 51 cases of type 2 diabetes and grade 2 hypertension (DH2 group), and 54 cases of type 2 diabetes and grade 3 hypertension (DH3 group).Meanwhile, 40 people without diabetes and hypertension were enrolled as the control group.The serum Giα-2 and NGAL levels in each group were detected by ELISA.The influence factors of Giα-2 and NGAL were analyzed by multiple linear regression analysis.Results The level of Giα-2 in the DS group was lower than that in the control group, at the same time, the levels of Giα-2 in the DH1 and DH2 and DH3 groups were higher than that of the DS group, and the DH3 group was the highest (all P<0.05).The level of NGAL in the DS group was higher than that of the control group, with the increase of hypertension grades, NGAL increased in the DH1 and DH2 and DH3 groups (all P<0.05).The results of the multivariate linear regression analysis showed that Giα-2 was positively correlated with systolic blood pressure (SBP) (r=0.54, P<0.05), and NGAL was positively correlated with SBP and fasting blood-glucose (FBG) (r=0.55 and 0.14, both P<0.05).Further multiple linear regression analysis showed that SBP was an independent influence factor for Giα-2 level, meantime, SBP and FBG were independent influence factors for NGAL level.Conclusion Serum levels of Giα-2 and NGAL increase in patients with type 2 diabetes and hypertension, and the changes in levels of Giα-2 and NGAL have a certain influence on the occurrence of type 2 diabetes and hypertension.关键词
2型糖尿病/高血压/抑制性G蛋白α亚基-2/中性粒细胞明胶酶相关脂质运载蛋白Key words
type 2 diabetes mellitus/hypertension/inhibitory G-protein subunit Gi α-2/neutrophil gelatinase-associated lipocalin分类
医药卫生引用本文复制引用
马爽,李宝新,张云良,常文龙,王翯,张鑫,郭淑芹..2型糖尿病合并不同分级高血压患者血清Giα-2、NGAL水平变化及意义[J].山东医药,2017,57(33):5-8,4.基金项目
国家自然科学基金项目(81500644) （81500644）
河北省医学科学研究重点课题计划(20160282). （20160282）
