山东医药2017，Vol.57Issue(33)：16-19,4.DOI:10.3969/j.issn.1002-266X.2017.33.005
血清胆红素水平与2型糖尿病肾病肾衰竭患者左室舒张功能的相关性
Correlation analysis between serum bilirubin level and left ventricular diastolic function in type 2 diabetic nephropathy patients with renal failure
摘要
Abstract
Objective To investigate the relationship between serum bilirubin level and left ventricular diastolic function in patients with type 2 diabetic nephropathy (DKD) combined with renal failure.Methods Totally 103 cases of patients with type 2 DKD and renal failure were selected as the observation group.According to the level of urinary albumin/creatinine ratio (UACR), the patients were divided into the normal albuminuria group (NA group, n=34), microalbuminuria group (MA group, n=39) and macroalbuminuria group (OA group, n=30).On the basis of diagnostic criteria of left ventricular diastolic dysfunction (LVDD), patients were divided into patients with LVDD (LVDD group, n=43) and patients without LVDD (non-LVDD group, n=60).In addition, 58 cases of health volunteers were taken as the control group.The levels of serum total bilirubin (TBIL), direct bilirubin (DBIL), and indirect bilirubin (IBIL) in each group were analyzed by Automatic biochemical analyzer.Meanwhile, the left ventricular mass index (LVMI), end-diastolic ventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), and left ventricular end-diastolic volume (LVEDV), and early diastolic blood flow velocity E peak/diastolic late A peak (E/A) were measured by color Doppler ultrasonography.Then , we analyzed the correlation between serum TBIL, DBIL, IBIL levels and left ventricular diastolic function.Results Compared with the control group, the levels of serum TBIL, DBIL and IBIL of the observation group significantly decreased (all P<0.05).Compared with the NA group, the levels of serum bilirubin of MA group and OA group were significantly lower (P<0.05), the level of serum bilirubin in the OA group was lower than that of the MA group (all P<0.05), and the level of serum bilirubin in the LVDD group was lower than that of the non-LVDD group (P<0.05).The levels of LVMI, LVPWT, LVEDD and IVST of the observation group were significantly higher than those of the control group (all P<0.05), while the levels of LVEF, LVEDV and E/A were significantly lower than those of the control group (all P<0.05).The serum TBIL level was negatively correlated with IVST, LVEF and E/A of patients with DKD (r=-0.708,-0.716,-0.703, respectively;all P<0.05), and was positively correlated with LVMI, LVPWT, and LVEDD (r=0.727, 0.729,0.732, respectively;all P<0.05).Serum DBIL level was negatively correlated with IVST and E/A (r=-0.721,-0.719;both P<0.05), and was positively correlated with LVMI and LVPWT (r=0.706,0.698;both P<0.05).Serum IBIL level was negatively correlated with IVST, LVEF and E/A (r=-0.705,-0.702,-0.651, respectively;all P<0.05), and was positively correlated with LVMI, LVPWT and LVEDD (r=0.713,0.719,0.723, respectively;all P<0.05).Conclusion The level of serum bilirubin could reflect the state of disease in type 2 DKD patients with renal failure, which is closely related to left ventricular diastolic function.关键词
糖尿病肾病/肾衰竭/胆红素/左室舒张功能/相关性分析Key words
diabetic nephropathy/renal failure/bilirubin/left ventricular diastolic function/correlation analysis分类
医药卫生引用本文复制引用
方云云,罗霞,徐燕,郭宁,吕美珍,孙云松..血清胆红素水平与2型糖尿病肾病肾衰竭患者左室舒张功能的相关性[J].山东医药,2017,57(33):16-19,4.基金项目
山东省自然科学基金项目(2016ZRB14388). （2016ZRB14388）
