陕西中医2017，Vol.38Issue(9)：1298-1300,3.DOI:10.3969/j.issn.1000-7369.2017.09.064
高载药量鼻用丹参酮IIA亚微乳制备工艺研究
A study on preparation of high drug-loading Tanshinone IIA nasal submicron emulsion
摘要
Abstract
Objective: The unique phase inversion technique was adopted to prepare high drug-loading Tanshinone IIA nasal submicron emulsion.Method: Dissolve Tanshinone IIA in anhydrous ethanol, and transfer the above solution into the round-bottomed flask.After adding soybean oil and oil, recover the entire ethanol of the system under vacuum condition.Until the Tanshinone IIA transferred to the oil phase completely , submicron emulsion was prepared by the use of the high pressure homogenization method.Orthogonal design was used to optimize the prescription and preparation techniques with the high pressure homogenization conditions as well as the dosages of emulsifier and stabilizer investigated.Results: The optimum conditions were as follows: the amount of drug loading was 0.5 ％, and the amount of S-75 was used as emulsifier 3 ％,F-68 was 1 ％, and the amount of oleic acid was 0.2 ％.The best conditions for the preparation process: the homogeneous pressure is 400 bar, the homogenization time was 16 min and the temperature was 35 ℃.The Tanshinone IIA submicron emulsion in preparation had a good stability with drug-loading 0.5 ％ and the average particle size 221 nm.Conclusion: The optimized technology in this experiment is stable and feasible.And the higher drug-loading than conventional methods can satisfy the requirement of different administration routes.关键词
丹参酮IIA/鼻用制剂/中药制药工艺Key words
Tanshinon Ⅱ/Nose drops/Pharmaceutical technology分类
医药卫生引用本文复制引用
张岁玲,郭琳,史亚军,梁玉琳,王瑜..高载药量鼻用丹参酮IIA亚微乳制备工艺研究[J].陕西中医,2017,38(9):1298-1300,3.基金项目
陕西省教育厅科研计划项目(15JK1202) 陕西中医药大学科研创新基金项目(14XJZR01) （15JK1202）
