陕西中医2017，Vol.38Issue(9)：1308-1310,3.DOI:10.3969/j.issn.1000-7369.2017.09.068
手掌参醇提物的药效学研究
Pharmacodynamics research on the activity of Gymnadenia conopsea
摘要
Abstract
Objective:To study the pharmacological activity of Gymnadenia conopsea R.Br and lay the foundation for the clinical practice of the Gymnadenia conopsea R.Br.Methods: Prepare the alcohol extract of Gymnadenia conopsea R.Br, and the sedative activity was observed by the frequencies of spontaneous activity of mice.And the analgesic effect was estimated by the mice writhing test caused by acetic acid and the hot-plate test.The anti-fatigue and anti-oxidant effects were investigated by the load bearing swimming test and the DPPH radical scavenging effect test and ABTS radical scavenging effect test respectively.Results:The inhibitory rates of the spontaneous activities of the mice were 51.2％, 44.9％ and 22.5％ respectively.The inhibition rates of wrinkle reaction induced by acetic acid was 48.7％, 32.9％ and 24.3％ respectively;the increase rates of pain threshold was 43.8％, 24.5％ and 13.6％ respectively;the prolongation rates of swimming time was 37.1％, 29.0％ and 14.5％ respectively;the radical scavenging rates of DPPHwere 86.1％, 51.3％ and 24.8％respectively;the radical scavenging rates of ABTS were 88.7％, 59.6％ and 29.3％ respectively.Conclusion:The Gymnadenia conopsea R.Br had favorable effect of sedative, analgesic, anti fatigue and antioxidant, laying the foundation for the further clinical application.关键词
手掌参/药效学/动物,实验/小鼠Key words
Gymnadenia conopsea (L.) R.Br/Pharmacodynamics/Animal experimentation/Mice分类
医药卫生引用本文复制引用
何侃亮,李博,纪明春..手掌参醇提物的药效学研究[J].陕西中医,2017,38(9):1308-1310,3.
