实验动物与比较医学2017，Vol.37Issue(4)：278-282,5.DOI:10.3969/j.issn.1674-5817.2017.04.004
柘木提取物抗胃肠道肿瘤的免疫机制研究
Immunologic Mechanism of Inhibition on Gastrointestinal Tract Tumors of ZHEMU Extract
谢家骏 1张国明 2乔正东 3陆宏祺 4严惠芳 5成苗5
作者信息
- 1. 上海中医药大学,上海201203
- 2. 上海市中药研究所,上海201400
- 3. 上海雷允上药业有限公司,上海201400
- 4. 上海市浦东医院,201399
- 5. 上海医药工业研究院,上海201203
- 折叠
摘要
Abstract
Objective To observation the changes of immune function in normal or tumor bearing animal after dose ZHEMU extract.Methods The carbon particle clearance test,macrophage phagocytosis test.NK cells activity and lymphocyte transformation in tumor bear animal are detected.Results The carbon granula clearance ability and phagocytosis of macrophage cell in abdominal on normal mice,and the lymphocyte transformation and natural killer (NK) cell activity in tumor bearing mice were enhanced after dosing,and the lowest effective dose were 0.3 g/kg,equivalent to the crude herb 5.46 g/kg,which was 1.3 times of clinical daily dose.Conclusions ZHEMU extract can restrain the growth of gastrointestinal tract tumors,and its mechanism may be related to the direct inhibition of the gastrointestinal tract cancerous cells growth and the improvement of the body's specific and non-specific immune function.关键词
柘木提取物/胃肠道肿瘤/抗肿瘤作用/免疫功能Key words
ZHEMU extract/Gastrointestinal tract tumors/Anti-tumor activity/Immune function分类
生物科学引用本文复制引用
谢家骏,张国明,乔正东,陆宏祺,严惠芳,成苗..柘木提取物抗胃肠道肿瘤的免疫机制研究[J].实验动物与比较医学,2017,37(4):278-282,5.
