实验动物与比较医学2017，Vol.37Issue(4)：320-323,4.DOI:10.3969/j.issn.1674-5817.2017.04.013
氧化苦参碱对小鼠哮喘模型保护作用的初步研究
The Protective Effect of Oxymatrine on Asthma Mice
摘要
Abstract
Objective To study the protective effect of Oxymatrine (OMT) on asthma mice.Methods The asthmatic BALB/c mice were induced by ovalbumin (OVA) and aluminium hydroxide.The general situations and weights of mice were observed every day.Then these mice were treated by using OMT and/or dexamethasone and were sacrificed at 5 or 15 days after treatment.The bronchoalveolar lavage fluid (BALF) and lung tissue of mice were obtained.Their pathological reaction was observed through HE stain.The total number of cells and eosinophilscells in BALF were counted.Result OMT can improve the weights of asthma mice.On day 5 and 15,the pathological reactions of the lung tissue in each treatment groups were the same with that of the asthma group,but the number of inflammatory cells in lung tissue was much less than that of the asthma group.The total number of cells and eosinophils cells in BALF were reduced compared with the asthma group (P＜0.05 or P＜0.01).Conclusion OMT has protective effect on the asthma mice.关键词
氧化苦参碱(OMT)/哮喘/病理变化/保护作用/小鼠Key words
Oxymatrine(OMT)/Asthma/Pathological changes/Protection/Mice分类
生物科学引用本文复制引用
兰露莎,赵兵兵,杨红宇,罗红,江滟..氧化苦参碱对小鼠哮喘模型保护作用的初步研究[J].实验动物与比较医学,2017,37(4):320-323,4.基金项目
贵州省科技厅省科技合作计划项目(黔科合LH字[2016]7369) （黔科合LH字[2016]7369）
