同济大学学报（医学版）2017，Vol.38Issue(4)：17-20,4.DOI:10.16118/j.1008-0392.2017.04.004
bFGF及FGFR-2在胃癌组织淋巴管生成中的意义
Expression of bFGF and FGFR-2 in gastric cancer and its clinicopathological significance
摘要
Abstract
Objective To investigate the expression of basic fibroblast growth factor (bFGF) and basic fibroblast growth factor receptor-2 (FGFR-2) in gastric cancer and their clinicopathological significance.Methods Immunohistochemical technique were used to detect the expressions of bFGF,FGFR-2 and D2-40 in 59 samples of gastric cancers and adjacent gastric tissues.Results The expressions of bFGF (69.5%,41/59) and FGFR-2 (64.4%,39/59) in gastric cancers were significantly higher than those in adjacent gastric tissue (P<0.05).The expressions of bFGF and FGFR-2 were positively correlated with lymph node metastasis and tumor infiltration depth.The lymphatic microvessel density (LMVD) in gastric cancer was significantly higher than that in normal gastric tissue (10.89±3.67 vs 3.58±0.96,P<0.05),which was correlated with lymph nodes metastasis and the expressions of bFGF and FGFR-2 (P<0.05).Conclusion The expression of bFGF and FGFR-2 is higher in gastric cancer,which might be associated with lymphangiogenesis and contribute to invasion and metastasis in gastric cancer.关键词
胃肿瘤/碱性成纤维细胞生长因子/成纤维细胞生长因子受体-2/微淋巴管密度Key words
gastric neoplasm/basic fibroblast growth factor/basic fibroblast growth factor receptor-2/lymphatic microvessel density分类
医药卫生引用本文复制引用
胡成乙,嵇晶晶,王晓菲,张晓辉,孙鹰,王立峰..bFGF及FGFR-2在胃癌组织淋巴管生成中的意义[J].同济大学学报（医学版）,2017,38(4):17-20,4.基金项目
黑龙江省教育厅科学技术研究项目(11541142) （11541142）
