同济大学学报（医学版）2017，Vol.38Issue(4)：41-44,48,5.DOI:10.16118/j.1008-0392.2017.04.009
实验犬左心耳封堵麻醉方法探讨
Anesthesia method for left atrial appendage occlusion in dogs
邢欢 1赵国浩 1纪东峰 1张鑫鑫 1王芬1
作者信息
- 1. 同济大学附属第十人民医院麻醉科,上海 200072
- 折叠
摘要
Abstract
Objective To investigate the anesthetic methods for occlusion of left atrial appendage in dogs.Methods Twenty-two Labrador dogs undergoing operation for occlusion of left atrial appendage were randomly assigned into combination group and pentobarbital pentobarbital group with 11 animals in each group.Dogs in pentobarbital group received 3% sodium pentobarbital intraperitoneally for anesthesia and those in combination group received the intramuscular injection with 0.1ml/kg xylazole and intraperitoneal injection with 0.5ml/kg sodium pentobarbital.During the operation mean blood pressure (MBP),heart rate (HR),ECG,respiratory rate,blood oxygen saturation were monitored continuously.Ephedrine,atropine and isoproterenol were used to maintain blood pressure and heart rate,respectively.Sedation,pain scale and effects of muscle relaxation were evaluated at 5min (T1),10min (T2),15min (T3) and 30min (T4) after anesthetic injection.Hemodynamic parameters were measured before operation (t0),and at different time points of intraoperative 5min (t1),10min (t2),20min (t3),30min (t4),60min (t5),90min (t6) and 120min (t7).The times of awakening and eating were observed.Results Compared with pentobarbital group,the dosage of atropine and isoproterenol in combination group were significantly reduced.The sedation,analgesia and muscle relaxation scores at T4 were significantly reduced in combination group.MAP and HR at T3 to T7 in combination group were significantly increased,earlier awaking and eating time were observed in the combination group.Conclusion Combined pentobarbital sodium with pentobarbital is safe and feasible for left atrial appendage occlusion operation under general anesthesia with spontaneous respiration in dogs.关键词
左心耳封堵术/麻醉/陆眠宁/戊巴比妥钠/犬Key words
left atrial appendage closure/anesthesia/xylazole/sodium pentobarbital/canine分类
医药卫生引用本文复制引用
邢欢,赵国浩,纪东峰,张鑫鑫,王芬..实验犬左心耳封堵麻醉方法探讨[J].同济大学学报（医学版）,2017,38(4):41-44,48,5.
