同济大学学报（医学版）2017，Vol.38Issue(4)：55-59,5.DOI:10.16118/j.1008-0392.2017.04.012
血清胱抑素C水平与慢性心力衰竭患者预后的关系
Association between serum cystatin C levels and prognosis in heart failure patients
摘要
Abstract
Objective To investigate the association between serum cystatin C levels and the prognosis of patients with chronic heart failure.Methods Three hundred and fifty one patients with decompensated chronic heart failure (HFrEF) admitted in heart failure department from March 2013 to December 2015 were enrolled in the study,221 patients with preclinical heart failure admitted in the same period were selected as the control group.The serum cystatin C levels were measured at admission in two groups.ROC curve was applied to analyze the association between serum cystatin C and chronic heart failure and then best cut-off value of serum cystatin C was chosen.The value of systatin C in prognosis of patients was analyzed by multivariate Logistic regression.Results Serum cystatin C levels in HFrEF and control groups were 1.99±1.78 and 1.31±0.71,respectively (P<0.001).Cystatin C was positively correlated with NT-proBNP (r=0.215,P<0.001),while not correlated with hypersensitivity CRP and hypersensitivity TnT.The area under ROC curve of cystatin C was 0.628,taking1.47 as cut-off value of cystatin the sensitivity and specificity for chronic heart failure were 71.8% and 50.0% respectively.Among 351 HFrEF patients,there were 158 cases with cystatin<1.47 and 193 cases with cystatin C≥1.47,after followed up for a median of 606 days,the cases of all-cause death in two groups were 32 and 71,respectively (P<0.001).Multivariate logistic regression showed that cystatin C was not significantly associated with the prognosis of HFeEF patients (P=0.694).Conclusion Serum cystatin C levels are increased in patients with chronic heart failure,but it may be not used as a prognostic indicator for patients.关键词
心力衰竭/胱抑素C/预后Key words
heart failure/cystatin C/prognosis分类
医药卫生引用本文复制引用
朱琛颖,巩昕,于萍,范慧敏..血清胱抑素C水平与慢性心力衰竭患者预后的关系[J].同济大学学报（医学版）,2017,38(4):55-59,5.基金项目
国家自然科学基金(81470393) （81470393）
上海市卫计委项目(2014ZYJB0502,ZY3-LCPT-2-1003) （2014ZYJB0502,ZY3-LCPT-2-1003）
