世界中医药2017，Vol.12Issue(7)：1559-1561,1565,4.DOI:10.3969/j.issn.1673-7202.2017.07.019
银屑灵片对寻常型进展期银屑病肥胖患者血清瘦素及Wnt5a的影响
Influence of Yingxieling Tablet on Serum Leptin and Wnt5a in Patients of Acute Psoriasis Vulgaris with Obesity
摘要
Abstract
Objective:To assess the influence of Yinxieling tablets on serum leptin and Wnt5a in patients of acute psoriasis vulgaris with obesity.Methods:Sixty cases were randomly divided into a control group of 30 cases and an observation group of 30 cases receive treatment in dermatology clinic of traditional chinese medicine hospital of guangdong province from January 2017 to May 2017.Patients in control group were treated with compound clobetasol propionate ointment for external use,while patients in the observation group were treated with Yinxieling tablets and compound clobetasol propionate ointment,4 weeks for treatment.The research was aim to compare the clinical effect of the two groups,evaluate the degree of skin lesion and BMI before and after treatment,and monitor the levels change of serum leptin and Wnt5a.Results:The effectiveness in the observation group is 96.7％,which was higher than that in the control group 73.3％ (P ＜0.05);The PASI,BMI,and Wnt5a of the patients in the observation group were lower than those of the control group(P ＜ 0.05),but the level of leptin in both groups is not statistically different before and after treatment (P ＞ 0.05).Conclusion:The treatment with Yinxieling tablets was proved to be effective in acute psoriasis vulgaris with obesity,which can lower PASI,BMI and the level of Wnt5a.The mechanism may be associated with the regulation of Wnt5a levels in the blood to promote Thl/Th2 cytokines ratio balance and alleviate the body state of chronic inflammation.关键词
银屑病/银屑灵片/肥胖/瘦素/Wnt5aKey words
Psoriasis Vulgaris/Yinxieling Tablet/Obesity/Leptin/Wnt5a分类
医药卫生引用本文复制引用
邓家侵,何梓阳,刘全知,伍慧媚..银屑灵片对寻常型进展期银屑病肥胖患者血清瘦素及Wnt5a的影响[J].世界中医药,2017,12(7):1559-1561,1565,4.基金项目
广东省中医药局科研项目(20161105) （20161105）
