生物技术通报2017，Vol.33Issue(9)：56-63,8.DOI:10.13560/j.cnki.biotech.bull.1985.2017-0354
乳铁蛋白抗菌机理研究进展
Research Progress on Antibacterial Mechanism of Lactoferrin
摘要
Abstract
Lactoferrin(LF)is a monomer glycoprotein in mammalian colostrum with multi biological activities,thus it plays a vital role in initial immunologic reconstitution for young mammals. Previous studies have discovered that enzymatic hydrolysates of lactoferrin have enhanced antibacterial activity compared to lactoferrin because more active antibacterial peptides were produced by the enzymolysis. At present, molecular mechanism of antibacterial function of lactoferrin is still unclear although many antibacterial activities of lactoferrin were reported. In this paper,combination of the bacterial cell membranes and the antibacterial activity of enzymatic hydrolysates were taken as the breakthrough point,and the process of LF acting in antibacterial function was explored. It was considered that the mechanism of the antibacterial function of lactoferrin was that the structure of lactoferrin changed following binding to bacterial surface,then the sensitive restriction enzyme cutting sites of lactoferrin were exposed,and many antibacterial peptides were released after enzymolysis ;subsequently the peptides destroyed the membrane structures of bacterial cells,and thus the purpose of the bacteriostasis or sterilization achieved. In summary,the elucidation of antibacterial mechanism of lactoferrin provides the theoretical basis for developing active proteins with stronger antibacterial ability.关键词
乳铁蛋白/抗菌活性/抗菌肽/膜结合Key words
lactoferrin/antibacterial activity/antimicrobial peptide/membrane binding引用本文复制引用
裴杰,褚敏,包鹏甲,阎萍,郭宪..乳铁蛋白抗菌机理研究进展[J].生物技术通报,2017,33(9):56-63,8.基金项目
国家自然科学基金项目(31402034),国家现代农业(肉牛牦牛)产业技术体系建设专项资金(CARS-37),牦牛遗传资源与育种(CAAS-ASTIP-2014-LIHPS-01) （31402034）
