神经调节蛋白-1对脓毒症大鼠心肌组织炎症和心肌细胞凋亡的影响OACSTPCD
Effects of neuregulin-1 on myocardial inflammation and cardiomyocyte apoptosis in rats with sepsis
目的 研究神经调节蛋白-1(neuregulin-1,NRG-1)对脓毒症大鼠心肌组织炎症和心肌细胞凋亡的影响.方法 雄性(8-10周)SD大鼠随机分为脓毒症组(n=10)、脓毒症NRG组(n=10)、假手术组(n=5)及假手术NRG组(n=5).脓毒症组和脓毒症NRG组建立盲肠结扎穿孔模型(cecal ligation puncture,CLP),假手术NRG组和脓毒症NRG组手术前30 min尾静脉注射重组人神经蛋白1(rhNRG-1,0.0…查看全部>>
Objective To explore the effect of neuregulin-1 (NRG-1) on myocardial inflammation and cardiomyocyte apoptosis in rats with sepsis.Methods Male (8-10 weeks old) SD rats were randomly divided into sepsis group (n =10),sepsis NRG group (n =10),sham group(n =5) and sham NRG group(n =5).The cecal ligation puncture(CLP) sepsis model was established in sepsis group and sepsis NRG group.The rats were injected with rhNRG at the dose of 0.01 μg/g through tail vein 30…查看全部>>
魏雅念;王龙;王鑫;付海霞
武汉大学人民医院麻醉科,武汉430060武汉大学人民医院麻醉科,武汉430060武汉大学人民医院心内科河南省人民医院心内科
医药卫生
脓毒症神经调节蛋白-1心肌损伤炎症因子凋亡
sepsisneuregulin-1 (NRG-1)myocardial injuryinflammatory factorapoptosis
《山西医科大学学报》 2017 (8)
S100B/RAGE通路对心衰小鼠室性心律失常及电重构的影响及机制研究
763-768,6
国家自然科学基金资助项目(81500255)河南省自然科学基金资助项目(201602262)
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