山西医科大学学报2017，Vol.48Issue(8)：783-787,5.DOI:10.13753/j.issn.1007-6611.2017.08.006
甘草酸二铵脂质配位体对非酒精性脂肪性肝病糖脂代谢的影响
Effects of diammonium glycyrrhizinate lipid ligand on glucolipid metabolism in nonalcoholic fatty liver disease
摘要
Abstract
Objective To explore the therapeutic effect of diammonium glycyrrhizinate lipid ligand (DGLL)on nonalcoholic fatty liver disease(NAFLD) and glucolipid metabolism.Methods Sixty-six NAFLD patients were randomly divided into DGLL group(diammonium glycyrrhizinate enteric-coated capsule) and PPC group(polyene phosphatidyl choline capsule).The changes of serological indicators such as transaminase,blood lipid,fasting insulin(FINS) and HOME-IR were observed after treatment for 1 and 3 months,and the degree of liver steatosis was observed after treatment for 3 months.Results The level of transaminase reduced after treatment for 1 month in DGLL group and PPC group(P ＜ 0.05);both transaminase and blood lipid reduced after treatment for 3 months in the two groups(P ＜ 0.05),the levels of transaminase in the two groups at 3 month after treatment were lower than that at 1 month.The levels of transaminase and blood lipid were significantly lower in DGLL group than in PPC group.Both FINS and HOME-IR reduced after treatment for 3 month in DGLL group(P ＜ 0.05).The level of leptin reduced and the level of adiponectin elevated after 3-month treatment in the two groups(P ＜ 0.05),however,there was no statistical significance between the two groups (P ＞ 0.05).The degree of liver steatosis in DGLL group was obviously improved after treatment for 3 months (P ＜ 0.05).Conclusion DGLL and PPC could significantly reduce the levels of transaminase and lipid in NAFLD patients,and the effect is better after treatment for 3 months.Moreover,DGLL is better than PPC in lowering transaminase and blood lipid.Long term use of DGLL could affect the lipid metabolism of NAFLD patients by reducing leptin,elevating lipid levels,and improving insulin resistance and liver fat variability.关键词
甘草酸二铵脂质配位体/多烯磷脂酰胆碱胶囊/非酒精性脂肪性肝病Key words
diammonium glycyrrhizinatelipid ligand/polyene phosphatidylcholine capsule/nonalcoholic fatty liver disease分类
医药卫生引用本文复制引用
方媛,刘欣,史海涛,赵刚,程妍,崔小萌..甘草酸二铵脂质配位体对非酒精性脂肪性肝病糖脂代谢的影响[J].山西医科大学学报,2017,48(8):783-787,5.基金项目
天晴肝病研究基金资助项目(TQGB20140095) （TQGB20140095）
