山西医科大学学报2017，Vol.48Issue(8)：791-794,4.DOI:10.13753/j.issn.1007-6611.2017.08.008
雌激素对去卵巢大鼠焦虑行为及杏仁核c-fos表达的影响
Effects of estradiol on anxiety-like behavior and amygdala c-fos expression in ovariectomized rats
苏晓云 1贺继平 2郑华3
作者信息
- 1. 山西医科大学汾阳学院护理学系护理人文教研室,汾阳032200
- 2. 山西医科大学汾阳学院基础医学部解剖教研室
- 3. 重庆师范大学体育学院
- 折叠
摘要
Abstract
Objective To explore the influence of estradiol on anxiety-like behavior and amygdala c-fos expression and the possible mechanism of estradiol improving anxiety-like behavior of the ovariectomized(OVX) rats.Methods Thirty adult SD female rats were randomly assigned into 3 groups:sham group,OVX group and OVX + E2 group(ovariectomized rats treated with estradiol).The elevated plus maze was used to assess the anxiety-like behavior after 8-week estradiol treatment.Immunohistochemical staining was used to detect the c-fos expression in amygdala.Results Compared with sham group,open ann entry(OE),open arm time(OT),the percentage of OE and the percentage of OT significantly decreased in OVX group(P ＜0.01),while the number and area of amygdala c-fos expression significantly increased(P ＜ 0.05).Compared with OVX group,anxiety-like behavior was improved and amygdala c-fos expression decreased after 8-week estradiol treatment in OVX + E2 group(P ＜ 0.05).Conclusion The ovariectomy may induce the anxiety-like behavior,and estradiol may ameliorate the anxiety-like behavior in OVX rats by decreasing the amygdala c-fos expression.关键词
雌二醇/杏仁核/c-fos/焦虑样行为/去卵巢/大鼠Key words
estradiol/amygdala/c-fos/anxiety-like behavior/ovariectomized/rats分类
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苏晓云,贺继平,郑华..雌激素对去卵巢大鼠焦虑行为及杏仁核c-fos表达的影响[J].山西医科大学学报,2017,48(8):791-794,4.
