生殖医学杂志2017，Vol.26Issue(9)：869-873,5.DOI:10.3969/j.issn.1004-3845.2017.09.004
男性年龄与精子顶体酶活性及精子DNA碎片指数的相关性分析
Relationship between sperm acrosin activity & sperm DNA fragmentation index and male age
摘要
Abstract
Objective:To analyze the relationship between male age and sperm acrosin activity,sperm DNA fragmentation index (DFI).Methods:A total of 436 infertile men in our reproductive medical center from January to August 2016 were investigated.All the patients were conducted the examination of semen parameters,sperm acrosin activity and (or) sperm DFI.The patients were divided into 3 groups according to male age:＜30 years group,31-39 years group,and≥40 years group.Comparison and correlation analysis among their semen parameters,sperm acrosin activity and sperm DFI were conducted.Results:There were no significant differences in BMI,days of abstinence,semen volume among the three groups (P＞0.05).The percentage of morphologically normal sperm,progressive sperm rate and sperm motility,sperm acrosin activity in ≥40 years group were significantly lower (P＜0.05),but DFI was significantly higher than ＜30 years group and 31-39 years group (P＜0.05).There was a negative correlation between age and progressive sperm rate and sperm motility (P＜0.05).There were positive correlations between sperm acrosin activity and the percentage of morphologically normal sperm,progressive sperm rate and motility (P＜0.05).Sperm DFI was positively correlated with age,abstinence days,progressive sperm rate (P＜0.01),while it was negatively correlated with semen volume,semen concentration &.motility (P＜0.05).No correlation was found between sperm acrosin activity and DFI.Conclusions:Increase of male age can lead to the deterioration of progressive sperm rate,sperm motility,sperm acrosin activity and sperm DFI,and directly or indirectly affects male infertility.Preconception counseling and evaluation of fertility are recommended for elder men (≥40 years) with reproduction requirement.关键词
男性/年龄/顶体酶活性/精子DNA碎片指数/精液常规Key words
Male/Age/Sperm acrosin activity/Sperm DNA fragmentation index/Semen parameters引用本文复制引用
李雪瑶,杨菁,李洁,徐玲..男性年龄与精子顶体酶活性及精子DNA碎片指数的相关性分析[J].生殖医学杂志,2017,26(9):869-873,5.基金项目
国家自然科学基金(81401255) （81401255）
