生殖医学杂志2017，Vol.26Issue(9)：880-884,5.DOI:10.3969/j.issn.1004-3845.2017.09.006
微刺激全胚胎冷冻方案在高龄患者中的应用
Application of mild stimulation in whole embryo frozen cycle in elderly patients
摘要
Abstract
Objective:To investigate the application value of mild stimulation protocol in elderly patients.Methods:A total of 542 patients aged≥38 years undergone 1 020 cycles with mild stimulation mild stimulation and whole embryo frozen protocol in IVF/ICSI were retrospectively analyzed.The patients were divided into 3 groups according to the age:group A (38-39 years),group B (40-42 years),and group C (≥43 years).The FSH levels on the third day of the menstrual cycle,dosage of gonadotropin (Gn) used,Gn days,average number of oocytes retrieved,number of mature oocytes,number of embryos,number of frozen embryos and pregnancy outcome were compared among the three groups.Results:One hundred and nineteen cycles in 1 020 stimulation cycle were abandoned due to poor ovarian response,and the cycle cancellation rate was 11.67 ％.The oocytes retrieval of sixty nine cycles in 1 001 cycles was failure,and the oocytes retrieval rate was 93.11％.The oocytes retrieval of 932 cycles was successful,and the average number of oocytes retrieved was (1.98± 1.40).A total of 565 cycles got frozen embryos,and the embryo frozen rate was 60.62％.The average number of oocytes retrieved and the number of frozen embryos in B group were significantly higher than those in group C (P＜0.05).There was no significant difference in the number of oocytes retrieved (P＞0.05),but the FSH level on 3nd of menstrual cycle,Gn used days,number of mature oocytes,number of formed embryos & frozen embryo were significantly different among the three groups (P＜0.05).Among them,Gn used days,total doses of Gn used,number of mature oocytes,and number of frozen embryos in group B were significantly higher than those in group C (P＜0.05).The number of mature oocytes and number of frozen embryos in group C was significantly less than those in the other two groups (P＜0.05).A total of 585 transplant cycles were performed in 342 patients,the pregnancy rate per transplantation cycle was 20.00 ％,and the cumulative pregnancy rate of the transfer cycle was 34.21％.The cumulative pregnancy rate of initial cycle was 21.59％.The pregnancy rate was significantly decreased with the increase of age (P＜0.05).Conclusions:Elderly patients with mild stimulation and whole embryo frozen protocol can get relatively satisfactory pregnancy outcome,and it is a good choice.How to develop appropriate treatment protocol based on age,ovarian reserve function,and previous ovulation outcomes for the elder patients should be explored in further randomized controlled trials.关键词
微刺激方案/高龄/体外受精-胚胎移植Key words
Mild stimulation protocol/Elderly age/In vitro fertilization and embryo transfer引用本文复制引用
孔娜,刘景瑜,陈华,王玢..微刺激全胚胎冷冻方案在高龄患者中的应用[J].生殖医学杂志,2017,26(9):880-884,5.基金项目
国家自然科学基金青年科学基金项目(81601246) （81601246）
