生殖医学杂志2017，Vol.26Issue(9)：891-895,5.DOI:10.3969/j.issn.1004-3845.2017.09.008
35周岁以下女性囊胚冻融周期移植策略的探讨
The strategy of frozen-thawed blastocyst transfer in women less than 35 years old
摘要
Abstract
Objective:To investigate the strategy of frozen-thawed blastocyst transfer in women less than 35 years old,in order to provide guideline for maintaining a certain pregnancy rate of single transfer cycle.Methods:The young women less than 35 years old came to the reproductive center of Shenzhen Zhongshan Urology Hospital from Jan.1 2015 to Oct.1 2016 were enrolled in this study.The data of 1 539 frozen thawed blastocyst transfer cycles were analyzed.The transfer cycles were divided into four groups according to the quantity and quality of blastocyst:single high quality blastocyst group,double high-quality blastocysts group,single poor-quality blastocyst group,and double poor quality blastocysts group.The clinical pregnancy rate,implantation rate,early miscarriage rate,ongoing pregnancy rate and twin pregnancy rate were compared among the four groups respectively.Results:The clinical pregnancy rate (77.9％),implantation rate (61.0％),ongoing pregnancy rate (90.8％) in double high-quality group were significantly higher than those in single high-quality group,single poor-quality group and double poor-quality group (P＜0.05).The early miscarriage rate (8.3％) was significantly lower than those in other three groups,while the twin pregnancy rate (47.6％) was significantly higher than those in other three groups (P＜0.05).The clinical pregnancy rate (51.6％ vs.49.6％),ongoing pregnancy rate (80.1％ vs.80.2 ％),early miscarriage rate (18.5％ vs.18.9％) in single high-quality group were not significantly different to those in double poor-quality group (P＞0.05),while the twin pregnancy rate was significantly lower than that in double poor-quality group (2.7 ％ vs.27.0％,P＜0.05).The twin pregnancy rate in single poor-quality group (1.4％) was similar to single high-quality group (2.7 ％),but it was significantly lower than double high-quality group and double poorquality group,while the pregnancy rate (37.6％) was yet significantly lower than that in other three groups (P＜0.05).Conclusions.:Single high quality frozen thawed blastocyst can be preferred to transplant for women less than age 35 years.Two poor-quality frozen-thawed blastocysts may be chosen to transfer in order to improve the pregnancy rate of single transfer cycle,if there is no high-quality frozen-thawed blastocyst available.关键词
选择性单胚胎移植/冻融胚胎移植/双胎妊娠率/临床妊娠率Key words
Selected single-blastocyst transfer/Frozen-thawed cycles/Twin pregnancy rate/Clinical pregnancy rate引用本文复制引用
谭巧,莫美兰,陈现,胡晓东,黄春宇,陈文娜,曾勇..35周岁以下女性囊胚冻融周期移植策略的探讨[J].生殖医学杂志,2017,26(9):891-895,5.基金项目
深圳市科创委基础研究项目(JCYJ20160427113514229) （JCYJ20160427113514229）
